A new study spotlights nicotinamide riboside (NR), a form of vitamin B3, as a promising option to support brain health and slow Alzheimer’s progression. Researchers from the University of Delaware College of Health Sciences and the National Institute on Aging found that NR can cross the blood-brain barrier and may help preserve neurons and brain energy metabolism as people age.
Alzheimer’s disease remains a major health challenge worldwide, including Thailand, where an aging population increases demand for prevention and treatment strategies. Current therapies primarily address symptoms rather than the disease itself. The latest findings align with a broader interest in NAD+ precursors like NR as potential neuroprotective options because they help maintain cellular energy in the brain. Data from leading research institutions suggests NR could offer protective benefits against neurodegeneration.
In preclinical tests, NR supplementation improved mitochondrial function and reduced brain inflammation across several models. The study employed both laboratory and animal approaches to show NR supports neuronal survival and modulates pathways linked to neurotransmission and oxidative stress. While the results are encouraging, experts stress that human trials are essential before any clinical recommendations can be made.
Dr. Carlsson Ramirez, a neurologist specializing in aging and neurodegenerative diseases, notes that NR as a dietary supplement could add a biological dimension to current treatments. “If human studies confirm these findings, we may move closer to new options for managing neurodegeneration,” he says.
Within Thailand’s health landscape, NR could resonate with the country’s emphasis on accessible, natural health solutions. Many Thai families already blend traditional practices with modern medicine. NR’s natural origin may appeal to this preference, and rural communities could gain new avenues for maintaining cognitive health as information and access improve.
Thailand’s approach to aging healthfully often blends Western and Eastern medical ideas. Introducing NR would require careful integration with existing nutrition and wellness programs, ensuring safety and cultural acceptance. If future clinical research confirms benefit and safety, NR might become part of a broader strategy that includes diet, exercise, and social engagement to support brain health.
Looking ahead, human clinical trials will be decisive. Thai health authorities and research institutions can play a key role by supporting international collaborations and translating findings into practical guidelines. Until then, researchers urge readers to stay informed and consult healthcare professionals before considering any new supplement, due to potential interactions and individual health considerations.
In the near term, NR remains a subject of ongoing study. For now, a balanced diet, regular physical activity, mental stimulation, and social connection remain the core, practical steps Thai people can take to support cognitive health.