A Spanish study suggests that a very low-calorie ketogenic diet could slow biological aging by about six years. The finding is of growing interest to health professionals and people aiming to extend healthspan. As epigenetic aging—where biological age diverges from calendar age—gains attention, this research offers meaningful insights into dietary strategies.
In Thailand, obesity remains a public health challenge. Defined by a body mass index of 30 or higher, obesity is linked to accelerated aging at the epigenetic level, affecting DNA methylation and the body’s internal clock. The Spanish study reports an average reversal of about six years in epigenetic age after 180 days on a ketogenic plan, a result that could inform future Thai health strategies and interventions.
The ketogenic diet, originally developed to manage epilepsy, has become popular for weight loss due to its very low carbohydrate intake, typically under 50 grams per day. Critics point to the diet’s exclusion of whole food groups and possible increases in LDL cholesterol, which may raise heart disease risk over time.
In the study, participants were divided into normal-weight and obese groups, with a long-term follow-up component. At baseline, obese participants showed an epigenetic age roughly 4.4 years higher than their chronological age, while normal-weight participants showed a deceleration of about 3.1 years. Those who followed the ketogenic plan maintained an average epigenetic age deceleration of about 6.2 years after the program, signaling potential for slowing premature aging.
Beyond aging markers, participants also showed improvements in glucose and insulin levels, a relevant outcome given the higher type 2 diabetes risk among individuals with obesity. Experts caution that larger studies are needed to confirm the role of ketone bodies in epigenetic aging and to evaluate long-term safety and health effects.
Health professionals urge cautious interpretation. A senior cardiologist explains that benefits likely arise from weight loss and broader metabolic improvements rather than ketosis alone. They warn against assuming aging reversal without considering overall health gains. Another physician cautions about potential nutrient gaps and the current lack of long-term safety data, especially for vulnerable groups.
For Thai readers, adopting a ketogenic approach must consider traditional dietary patterns. Thai meals, which often feature rice and vegetables, may require thoughtful adaptation to align with ketogenic principles without sacrificing cultural preferences. Promoting balanced nutrition that respects Thai cooking styles can support healthier outcomes while remaining culturally appropriate.
Looking ahead, researchers call for more context-specific studies and practical dietary guidelines tailored to Thai populations. Collaboration with healthcare providers will be crucial to navigate risks and maximize benefits when considering such dietary shifts.
In summary, while the Spanish findings offer promising insights into how very low-calorie ketosis might influence aging markers, they also highlight the need for careful, personalized guidance and robust long-term evidence before broad adoption in public health.