As health-conscious individuals, it’s not uncommon for those of us in Thailand to turn to dietary supplements as a means of enhancing our well-being. However, recent research highlights alarming findings from a study published in JAMA Network Open in 2024, pointing out that certain popular supplements might pose significant risks to our liver’s health. This is particularly crucial given that the liver is central to our body’s ability to detoxify and metabolize substances, and damage to it can result in severe health repercussions, including liver failure.
The study identifies six specific botanical supplements known to be associated with liver toxicity: Ashwagandha, Black Cohosh, Garcinia Cambogia, Green Tea Extract, Red Yeast Rice, and Turmeric/Curcumin. These supplements, often marketed for conditions prevalent among middle-aged and older adults—such as arthritis and menopause symptoms—are found to be the top contributors to liver damage among such users. This raises a red flag for supplement consumers in Thailand, as herbal and botanical remedies are widely used and trusted in Thai culture for their perceived natural benefits.
Liver toxicity from these botanicals can manifest in both acute damage and cumulative effects from long-term use, potentially leading to liver failure that requires emergency intervention such as transplantation. The mechanism involves hepatocytes, the liver’s major cells, which, while responsible for detoxifying the body, can be overwhelmed and damaged by these substances. Importantly, as pointed out by Arun Jesudian, M.D., a transplant hepatologist, even natural compounds necessitate processing by the liver, risking significant harm.
In Thailand, where traditional herbal medicine often complements Western medical practices, these findings may have profound implications. The country is renowned for its herbal remedies, with a significant portion of the population relying on them for various ailments. However, this research indicates that there is an urgent need for greater awareness regarding the potential hepatotoxicity of supplements.
Experts stress the importance of vigilance when considering supplements. Don Rockey, M.D., highlights that anything ingested makes its initial metabolic stop at the liver, hence emphasizing the necessity for consumers to prioritize safety by researching and consulting healthcare providers before starting any supplement regimen. This is particularly vital if there are pre-existing liver conditions.
Furthermore, the regulatory landscape in Thailand might mirror the limitations seen in the U.S., where supplements are not as tightly controlled as pharmaceuticals. This adds an additional layer of complexity, as there may be unsafe substances or incorrect ingredients in the product due to labeling inaccuracies. Thai consumers are encouraged to look for supplements certified by third-party testers, such as NSF or USP, to ensure they are getting a safe product.
To mitigate risks, healthcare professionals in Thailand recommend several strategies: thorough research using trusted resources such as the LiverTox database, consultation with healthcare providers about any supplements being considered, careful scrutiny of herbal products claimed to support liver health, and regular health screenings including liver function tests. For those already consuming these supplements, checking in with a doctor to discuss potential risks and alternatives is highly advisable.
Ultimately, this research calls for a well-informed approach to supplement intake, grounded in scientific evidence and medical advice to safeguard liver health. As we advance forward in leveraging both traditional and modern healthcare practices, navigating these choices with caution becomes integral to maintaining robust health.