A new review of over-the-counter mood supplements helps clarify what might help for mild to moderate depression—and where evidence remains limited. The analysis examined 209 studies and was led by researchers from Southern Cross University, offering a clearer view for Thai consumers navigating a busy market of vitamins, herbs, and dietary products.
Depression is a leading cause of disability worldwide, including Thailand. Many people turn to mood boosters such as omega-3 capsules or herbal teas due to stigma around treatment, cost barriers, or hesitation about prescription medicines. In Thailand, rising health awareness and a thriving herbal-supplement scene linked to traditional medicine mirror global trends highlighted by the review.
The study focused on adults 18 to 60 and evaluated omega-3s, St John’s wort, saffron, probiotics, vitamin D, multivitamins, and other plant-based remedies. While these products are popular, researchers note that “surprisingly little research exists on these therapies compared with psychological or pharmaceutical treatments.” Only a few have enough evidence to offer moderate confidence; many, such as folic acid, zinc, Rhodiola, lavender, and lemon balm, have only one or two clinical trials and cannot yet be broadly recommended.
Moderate evidence supports certain supplements. Omega-3 fatty acids (especially high EPA content), St John’s wort, saffron, and vitamin D showed some benefit for mild to moderate depression. Curcumin (turmeric) and St John’s wort have also shown promise for less severe symptoms in government reviews, with effects sometimes approaching those of standard antidepressants. However, much of this evidence is for simpler cases; for more severe depression, benefits appear limited. Probiotics show potential in some scenarios but lack robust data for major depressive disorder.
The report also notes variability in dosages, quality, and actual ingredients in non-prescription products. Authorities in the UK, Australia, and Thailand have long warned about inconsistent standards, raising the risk of low potency or adulteration. St John’s wort, in particular, can interact with medications and cause adverse effects, highlighting the need for medical oversight.
A clinical psychologist from a leading Bangkok hospital says most over-the-counter products are safe for short-term, mild use, but there is still a risk of interactions. It is essential to consult a health professional before starting any supplement, especially if prescription antidepressants are in use. This perspective resonates in Thailand, where pharmacies stock a wide range of supplements and many people pursue alternative therapies alongside conventional care.
Another researcher involved in the review emphasizes that the strongest, most reliable evidence remains for approved medications and talk therapies. These modalities are standard because they are the most thoroughly studied.
Lifestyle changes—better diet, more physical activity, adequate sleep, and mindfulness or yoga—also show strong and growing evidence as effective depression strategies. Nutritional gaps, such as iron or vitamin B12 deficiencies, can mimic or worsen depressive symptoms. A balanced, nutrient-rich diet may offer benefits similar to supplements without the risks of variable product quality or drug interactions. Data from Thailand’s Mahidol University highlights diet and urban lifestyle factors affecting mental health among younger populations, aligning with broader findings.
Thai culture already embraces mindfulness and plant-based remedies, with local ingredients like turmeric and galangal common in food and health practices. Yet, as with Western supplements, rigorous scientific validation, standardization, and consumer guidance remain essential. A leading psychiatrist from a major Bangkok hospital cautions that herbal supplements should complement, not replace, proper medical assessment and treatment for significant depressive symptoms.
Depression often coexists with other health issues, such as thyroid problems or diabetes. Effective management should address these underlying conditions alongside mental health care. Thailand’s Ministry of Public Health advocates screenings and a balanced approach that combines evidence-based medical care with lifestyle changes.
The study’s authors note that while some herbal and nutritional supplements may help milder cases, most products lack enough evidence for definitive recommendations. Healthcare professionals and patients should be mindful of quality control, dosing, and potential interactions—a stance echoed by Thai medical authorities and the Thai FDA, which advocate cautious use and professional guidance.
Looking ahead, experts anticipate stronger clinical trials and improved regulations for supplement quality and labeling. As Thailand’s herbal innovation sector grows, researchers hope to pinpoint which traditional remedies are truly effective, enabling safer consumer choices.
For Thai readers seeking guidance, the consensus is clear: consult a healthcare professional—such as a general practitioner, clinical psychologist, or registered dietitian—before starting any herbal or nutritional supplement for depression, especially if prescription medications are involved or chronic conditions exist. Emphasize lifestyle improvements and rely on community mental health resources expanding under national health initiatives. Supplements can be part of a broader wellness plan, but they should not replace evidence-based therapies or a nutritious diet.
If you experience persistent sadness, loss of interest, or thoughts of self-harm, help is available through Thailand’s Department of Mental Health and community health centers nationwide.
Further context on the study is presented in reports from major outlets that discuss expert perspectives on whether supermarket treatments for depression work.