Recent research prompts clinicians to rethink the safety of Benadryl, whose active ingredient diphenhydramine is a sedating anticholinergic. Studies indicate that frequent, long-term use may be associated with a higher risk of dementia and Alzheimer’s disease, particularly among older adults. Thai doctors advocate discussing safer alternatives with healthcare providers.
The findings carry special weight in Thailand, where self-medication with antihistamines is common and the population is aging. Dementia already affects many families in Thailand, adding pressure to the healthcare system. Data from national health authorities and global health bodies underscores the importance of addressing modifiable risk factors to protect cognitive health later in life.
Diphenhydramine has been used since the 1940s for its antihistamine and sedating effects. By contrast, newer second-generation antihistamines provide effective allergy relief with fewer cognitive side effects. Global guidelines increasingly favor these safer options for adults and older adults.
Experts caution that one-off Benadryl use is unlikely to cause harm for most people. Risk rises with repeated, long-term use, especially in seniors. A prudent approach includes limiting use, avoiding daily reliance, and considering alternatives when appropriate. For intermittent symptoms, short courses of non-sedating antihistamines are commonly recommended.
In Thailand, second-generation antihistamines such as cetirizine and fexofenadine are widely available and generally considered safer for most patients. Regional practice guidelines align with these options as preferred first-line therapies for adults and older adults. Clinicians stress tailoring treatment to individual needs, including age, concomitant medications, and cognitive health.
Thai families often play a central role in health decisions, especially for elderly relatives. This cultural context highlights the need for clear guidance from healthcare providers and pharmacists. Public health messaging should emphasize medication reviews with professionals, particularly for those who frequently self-medicate or purchase drugs from local shops.
Experts call for continued research on how diphenhydramine and similar anticholinergics affect the brain over time, including in Asian populations where genetics and lifestyle may influence risk. In the meantime, healthcare systems can support safer choices by updating pharmacy education, enhancing patient counseling, and promoting safer over-the-counter options.
Practical guidance for readers:
- If Benadryl is used regularly, consult a clinician to review medications and discuss safer alternatives.
- Prefer non-sedating, second-generation antihistamines for ongoing allergy relief.
- For temporary symptoms, limit duration and frequency; seek professional advice for persistent allergies.
- Pharmacists and clinics should provide clear information about safer antihistamines to help patients make informed decisions.
This effort aligns with broader aims to protect cognitive health as Thailand’s population ages. Staying informed and engaging with healthcare providers helps ensure safer, effective allergy management.
Inquiries about allergy medications should be directed to a licensed healthcare professional. Public health campaigns will continue to promote safe medication practices and regular medication reviews for older adults.