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For centuries, the thick, gnarled roots of Pueraria mirifica have been unearthed from the misty forests of northern Thailand and lovingly brewed into potions or dried into powders with a singular promise—youthfulness restored. Known locally as กวาวเครือขาว (Kwao Krua Kao), this fascinating member of the legume family occupies a unique niche in both traditional Thai medicine and the budding landscape of natural health supplements worldwide. But what is the science behind its enduring popularity? And how does the legend of an ancient “elixir of youth” meet the scrutiny of the modern laboratory?