Puberty Prompts Brain Rewiring in Genetic Condition Linked to Autism, New Study Finds
Recent groundbreaking research from UCLA Health reveals that puberty triggers significant changes in brain connectivity, which may help explain why some children with chromosome 22q11.2 deletion syndrome, a rare genetic disorder, are at an increased risk for developing neuropsychiatric conditions like autism and schizophrenia. The findings, published in Science Advances, provide new insights into the biological mechanisms underlying these complex conditions, offering hope for future interventions.
Chromosome 22q11.2 deletion syndrome is caused by missing DNA on chromosome 22 and is known to be associated with a higher risk of autism and schizophrenia. Researchers from both UCLA and the Italian Institute of Technology utilized functional brain imaging on both humans and genetically modified mice to explore how this genetic anomaly affects neurodevelopment. They observed that certain brain regions involved in social skills and autism were hyperconnected before puberty and shifted to being under-connected post-puberty. These changes were linked to synaptic activity, with significant implications for affected individuals.