#Antimalarial

Brucea javanica, known locally as ราชดัด, sits at the crossroads of Thai folklore and modern medicine. For generations in Thailand, this bitter fruit has appeared in households and markets as a remedy for fevers, digestive issues, and malaria. Today, researchers are unpacking its chemistry and exploring both the promises and the cautions that come with traditional remedies.

Brucea javanica belongs to the Simaroubaceae family and grows across Southeast Asia. In Thailand, its small black fruit has long featured in herbal chests. In the North it is referred to as “ยาแก้ฮากขม” for bitter mouth and digestive discomfort, while other regions use names like กะดัด, ดีคน, เพียะฟาน, and มะลาคา. The plant’s widespread use across Thai communities reflects its adaptability to different health beliefs and local environments. Its cultural role extends beyond medicine; in some communities, it is part of protective charms, hinting at a spiritual layer to its pharmacological appeal.

In the folkloric landscapes and pharmacy cabinets of Thailand, the name ราชดัด (Brucea javanica) conjures images of bitter medicine, traditional healers, and a remedy with a mysterious allure. For generations, this humble plant—known by regional names like ดีคน, กะดัด, มะลาคา, and more—has been entrusted in Thai traditional medicine to counter fevers, digestive woes, “bitter mouth,” and even malaria. Today, as modern science takes the stage, researchers are piecing together the pharmacological tapestry that validates and, at times, complicates the centuries-old reputation of this remarkable fruit. As Thais and the world wake up to the promise—and potential pitfalls—of traditional remedies, Brucea javanica reminds us of the intricate balance between ancestral experience and evidence-based medicine.