#Appetite

In a groundbreaking discovery, scientists have unveiled a “neurobiotic sense”—a newly identified gut-to-brain communication system that lets the brain know, in real time, when your body has had enough to eat. This research, published by a team at Duke University School of Medicine in the scientific journal Nature, uncovers how specialized colon cells detect bacterial signals and quickly send appetite-suppressing messages to the brain, potentially reshaping our understanding of diet, obesity, and the intricate link between gut microbes and behavior (Neuroscience News; Nature Journal).

A new discovery reveals a real-time gut-to-brain signal that tells the brain we’ve had enough to eat. Researchers describe this as a neurobiotic sense. A study from Duke University School of Medicine, published in Nature, shows that colon cells detect bacterial signals and quickly curb appetite via the vagus nerve. This advances our understanding of diet, obesity, and the gut–brain connection, with practical implications for Thai health strategies.

For Thai readers, the research offers a fresh lens on weight management, cravings, and mood, highlighting the gut microbiome as a key factor alongside diet and willpower. With rising obesity and metabolic disorders in Thailand, these insights could shape future public health guidance, nutrition advice, and mental well-being interventions.

A new study shows that non-caloric sweeteners interact with the brain’s hunger signals in complex ways. Rather than a universal effect, responses vary across individuals. The research followed people with different weights and used modern brain imaging to see how sweeteners might influence hunger and fullness. The findings matter in Thailand, where sugary drinks and sweet flavors are deeply woven into daily life.

Researchers used neuroimaging to observe the hypothalamus, the brain’s hub for appetite control. They found that neural responses to non-nutritive sweeteners such as sucralose and aspartame differ by body mass index and metabolic health. In some participants, these sweeteners heightened appetite-related activity; in others, the response was more muted. This suggests that a person’s health context shapes how sugar substitutes affect desire for food.

New findings in Nature Metabolism show that non-caloric sweeteners may influence appetite signals in the brain, and responses vary by body weight. This adds depth to the idea that sugar substitutes are not a universal fix for weight management or diet-related health issues.

The study matters for Thailand, where sweetened beverages and snacks are common. Many people use zero- or low-calorie sweeteners to cut calories, but brain responses to these substitutes appear different among lean, overweight, and obese individuals. Practically, this could mean varying feelings of hunger or fullness after consuming these products, depending on weight status.