Timely IL-34 Signaling Offers New Hope for Thai Child Brain Health
A new study identifies interleukin-34 (IL-34) as a critical cue that guides early brain development by directing microglia, the brain’s immune cells, on when to prune synapses. Proper IL-34 timing helps build resilient neural networks and supports later emotional health, learning, and cognition. Researchers describe IL-34 as a signal that tells microglia when to start and stop pruning during infancy.
Traditionally, microglia were seen mainly as defenders against infection. The findings now show they actively shape brain architecture as well. Supported by national health research funding and dementia-focused philanthropic support, the work demonstrates that normal IL-34 signaling enables microglia to engage at the right moments. When IL-34 functions correctly, pruning proceeds in a balanced, developmentally appropriate way.
