#Brain Connectivity

A groundbreaking study published in Molecular Psychiatry reveals that LSD, unlike MDMA and d-amphetamine, alters brain connectivity in distinctive ways, reshaping our understanding of how these substances affect the human brain. Conducted by researchers at the University of Lübeck, this study is pivotal for psychiatry, underscoring the nuanced differences between substances often grouped under the “psychedelics” label.

The research utilized functional magnetic resonance imaging (fMRI) to observe brain activity in 25 healthy volunteers under the influence of LSD, MDMA, and d-amphetamine. The study found that while all three psychotropics disrupted communication within brain networks, LSD uniquely affected regions associated with self-awareness and sensory processing. These insights highlight the inaccuracy of lumping LSD with other psychedelics like MDMA, often wrongly presumed to have similar effects due to their shared primary action on serotonin 2A receptors.

In a groundbreaking study, researchers have identified unique features in the human brain that distinguish it from other primates. Conducted by neuroscientists including Professor Rogier Mars and Katherine Bryant, the study examined brain connectivity using MRI data to compare humans with chimpanzees and macaque monkeys—our closest living primate relatives. This research, detailed in Science Alert, uncovers significant differences in brain wiring that contribute to our advanced cognitive abilities and social behaviors.