#Brainaging

Researchers say a protein called ferritin light chain 1 (FTL1) can be dialled down to restore memory performance in aged mice, a finding described as a true reversal of age-related cognitive decline rather than simple slowing. The study used genetic tools and viral delivery to reduce FTL1 in the hippocampus, the brain’s memory centre, and reported that older mice regained memory and learning abilities comparable to much younger animals. Published in a leading ageing journal, the experiment points to iron-handling and cellular energy as central mechanisms in normal brain ageing and opens a new therapeutic avenue distinct from decades of Alzheimer’s research focused on amyloid and tau. For Thai readers worried about a parent’s forgetfulness or the growing social and economic cost of cognitive decline, the study brings hope but also important caveats about how mouse findings translate to humans.

A recent study making waves in the scientific and wellness communities suggests that the brains of dedicated meditators can appear nearly six years younger than their chronological age, raising fresh interest in the ancient practice among health-conscious Thais. According to an article from Psychology Today, people who regularly meditate may have brain ages that are on average 5.9 years younger than their calendar years would suggest, a finding that could reshape how both individuals and public health institutions address brain aging.

A landmark study published in Psychological Medicine has revealed that individuals suffering from major depressive disorder show signs of accelerated brain aging, offering new insights into the profound physical toll depression takes on the body. The research, which focused on a Japanese cohort, is one of the first to confirm that depression’s impact on brain structure extends beyond Western populations, emphasizing the global relevance of the findings and their implications for countries like Thailand.

A groundbreaking new study has identified N-cadherin, a protein molecule, as a key trigger for the differentiation of neural stem cells, paving the way for potential breakthroughs in treating brain aging and neurodegenerative diseases. This promising research, recently reported by Medical Xpress (source), suggests that manipulating N-cadherin activity could help regenerate brain tissue, offering renewed hope for individuals living with conditions like Alzheimer’s disease, Parkinson’s disease, or the effects of stroke.