#BrainDevelopment

A groundbreaking new study has revealed the essential role of an immune molecule, interleukin 34 (IL34), in fine-tuning brain development—a discovery that could reshape understanding of neurodevelopmental and neurodegenerative disorders. Conducted by researchers at Duke University and published in the journal Immunity on July 2, 2025, the study finds that IL34 acts as a key messenger, directing the brain’s own immune cells, known as microglia, on when and how to “prune” connections between neurons in early life. This process of synaptic pruning is fundamental, as it creates stronger, more efficient neural pathways underlying emotion, decision-making, and learning abilities (Duke University Medical School).

Doctors’ notoriously difficult-to-read handwriting has triggered a wave of legislative action worldwide and raised enduring questions for patients, pharmacists, and even policymakers. But why do so many healthcare professionals—and people in general—struggle to write clearly? Recent interdisciplinary research offers nuanced answers drawn from anthropology, neuroscience, and psychology, revealing that poor penmanship is far more than a simple lack of care or discipline. For Thais who depend on handwritten medical notes for prescriptions or hospital charts, understanding the roots of this phenomenon is crucial for both safety and effective communication.

A groundbreaking new study has found that preschool children’s brains respond differently when stories are shared through live book reading versus on a screen, suggesting that how children experience stories may impact key aspects of their social and cognitive development. The research, published in the journal Developmental Science, used advanced neuroimaging technology to observe children’s brain activity during both types of storytelling—a live reading from a book and a recorded story paired with images on a screen (PsyPost).

A wave of new research is sending shockwaves through the pediatric and parenting communities worldwide, revealing that many babies and young children may be routinely exposed to harmful chemicals while they sleep—potentially threatening their brain development. Studies published by the University of Toronto, widely reported by leading outlets such as Medical Xpress, CNN, and NDTV, found that children’s mattresses often emit worrying quantities of phthalates, flame retardants, and other substances linked to a host of neurological and developmental disorders, triggering calls from scientists for urgent action by manufacturers and regulators (MedicalXpress, CNN, NDTV).

Recent groundbreaking research from UCLA Health reveals that puberty triggers significant changes in brain connectivity, which may help explain why some children with chromosome 22q11.2 deletion syndrome, a rare genetic disorder, are at an increased risk for developing neuropsychiatric conditions like autism and schizophrenia. The findings, published in Science Advances, provide new insights into the biological mechanisms underlying these complex conditions, offering hope for future interventions.

Chromosome 22q11.2 deletion syndrome is caused by missing DNA on chromosome 22 and is known to be associated with a higher risk of autism and schizophrenia. Researchers from both UCLA and the Italian Institute of Technology utilized functional brain imaging on both humans and genetically modified mice to explore how this genetic anomaly affects neurodevelopment. They observed that certain brain regions involved in social skills and autism were hyperconnected before puberty and shifted to being under-connected post-puberty. These changes were linked to synaptic activity, with significant implications for affected individuals.

Recent research underscores the profound impact early life experiences have on shaping the brain’s communication networks, subsequently affecting cognition. This study, which delves into the formation of what are metaphorically deemed the brain’s “communication superhighways,” reveals that these pathways are crucial in cognitive development, particularly during the formative early years.

Understanding how early experiences shape brain development is of significant interest, not only within the scientific community but also for educators and policymakers in Thailand, where childhood development is a growing focus. The study highlights that the environments in which children grow up—whether rich in opportunities or fraught with challenges—can significantly alter neural connectivity, thereby affecting cognitive abilities later in life.