#Brainhealth

A new study in the Journal of Physiology reveals a strong liver–brain connection: ketones produced by the liver during exercise may support cognitive health, offering hope for those with liver challenges. Researchers from a leading U.S. university showed that when liver cells lose the ability to make ketones, brain energy and learning decline. Remarkably, endurance exercise could reverse these brain changes, hinting at a backup system that helps protect aging minds.

A recent study shows that natural hormone fluctuations during reproductive cycles can reshape the brain and sharpen learning abilities. Published in Neuron and led by researchers at a major U.S. university, the work demonstrates that rising estrogen levels alter neuron structure in the memory center of the brain and improve the brain’s ability to form mental maps of surroundings.

For Thai readers, this research reinforces that cognition is not fixed. Brain structure and function can shift with natural biological rhythms. The findings contribute to global conversations on gender, neuroscience, and education strategy, offering potential implications for how we approach teaching and student support in Thailand.

A groundbreaking new study reveals that the natural ebb and flow of hormones during the reproductive cycle can dramatically reshape the brain and sharpen learning abilities, promising to transform our understanding of cognition—and even hinting at new paths in personalized medicine. Published this week in the journal Neuron and led by researchers at the University of California, Santa Barbara, the research shows that cyclical changes in estrogen not only alter the physical structure of neurons in the memory-related hippocampus but also enhance the brain’s ability to form and maintain mental maps of our surroundings (Neuroscience News).

A growing body of scientific research is sounding the alarm on the mental toll of constant surveillance, warning that being persistently observed—in person or digitally—may be subtly eroding our ability to concentrate and remember. Recent studies reveal that the effects go deeper than mere discomfort, reaching into our unconscious brain and potentially impacting our day-to-day lives, including work, education, and social interaction (NewsNationNow, The Hill, LiveScience).

In a world increasingly equipped with surveillance cameras, digital tracking, data brokers, and online platforms where users are encouraged—or pressured—to display their lives, the sensation of constantly being watched is almost inescapable. For Thais, where CCTV cameras are prolific in Bangkok and major urban areas, digital footprints grow daily, and remote work or online coursework is on the rise, these findings hold powerful relevance. Just as the panopticon prison designed by philosopher Jeremy Bentham coerced prisoners into self-monitoring, our modern panopticon of digital and physical observation exerts its own psychological weight.

A wave of recent science highlights a troubling link between long work hours and brain changes. A multicenter study led by researchers in Asia found that people clocking more than 52 hours weekly showed notable alterations in brain regions tied to memory, decision-making, and emotional control. While the research sparked global discussions, it carries particular relevance for Thailand’s evolving labor market and rising demands on workers.

Data from the Thai workforce shows Bangkok consistently ranks as a city with high working hours, and nearly one in six employees report working more than 48 hours per week. This new evidence suggests that sustained overwork could contribute to cognitive and emotional challenges well beyond fatigue, underscoring the need for workplace and public health strategies in Thailand.

A flurry of new scientific findings has revealed that the stress of working long hours doesn’t just leave people feeling exhausted—it may actually alter the structure of the human brain. According to a major study led by researchers from South Korea and published in May 2025, individuals clocking more than 52 hours a week exhibited significant physical changes in brain regions tied to memory, decision-making, and emotional regulation, sparking fresh concerns about the risks of overwork worldwide—including in Thailand’s increasingly demanding labor market (The Times; CNN; Newsweek).

A groundbreaking new study published in the Journal of Physiology has unveiled a striking connection between the liver’s metabolic function and brain health, highlighting the crucial role of liver-produced ketones during exercise—and raising intriguing possibilities for combating cognitive decline, even among those with liver impairments. Conducted by researchers at the University of Missouri, the research demonstrates that when liver cells lose the ability to make ketones, cognitive and mitochondrial function in the brain suffer. Remarkably, endurance exercise was found to reverse these negative effects, suggesting a possible “backup system” that could protect the aging brain and offer new hope to individuals with liver disease (psypost.org).

A major new study has found that spending prolonged hours seated each day may shrink the brain and raise the risk of cognitive decline, regardless of how much a person exercises. The findings, which have generated global attention, suggest that even regular physical activity may not be enough to counteract the potentially damaging effects of extended sedentary behavior on brain health, especially in older adults. For Thai readers, who increasingly balance desk-based work with daily commutes and digital leisure time, the message is clear: simply hitting the gym may not be enough—reducing sitting time itself is essential for healthy brain aging.

A groundbreaking study shows that long hours of sitting may cause brain shrinkage and faster cognitive decline, even for those who exercise regularly. For Thai readers juggling desk jobs, commutes, and digital leisure, the message is clear: cutting sitting time is crucial for healthy brain aging, not just hitting the gym.

Researchers tracked thousands of older adults over seven years, using MRI scans and genetic data to assess brain changes. They found that more daily sitting correlated with greater loss of brain volume and faster cognitive decline, even among people who met physical activity guidelines. The effect was stronger among individuals carrying the APOE-e4 gene, a known risk marker for Alzheimer’s disease, underscoring the importance of early lifestyle interventions for at-risk groups. Data from studies conducted by leading health organizations informs this insight, while health reporters around the world have highlighted the finding’s implications for aging populations.

Researchers at a leading U.S. university have uncovered how dopamine, the brain’s reward signal, helps unlearn fear. The discovery, published in the Proceedings of the National Academy of Sciences, could transform treatments for anxiety and PTSD. For Thai readers, this points to new avenues for culturally sensitive therapies that emphasize safety and positive learning.

Across decades, scientists have known the amygdala drives both fear and its extinction. For Thais affected by traumatic events—natural disasters, traffic accidents, or the lingering impact of Covid-19—persistent anxiety and nightmares are common. The new insight into how the brain learns to feel safe offers hope for more effective, locally relevant therapies that reduce stigma around mental health.

A recent feature highlights seven everyday habits that doctors say raise stroke risk and should be avoided. Stroke remains a leading cause of disability and death worldwide, including Thailand, making prevention essential for families and communities.

Strokes, or cerebrovascular accidents, disrupt blood flow to the brain and can cause long-term disability. Data from global health bodies show tens of thousands of new stroke cases in Thailand each year, with substantial economic and caregiving impacts for families. Local health authorities emphasize prevention as a practical path to reduce these burdens.

Researchers at the Massachusetts Institute of Technology (MIT) have uncovered a crucial mechanism in the brain, revealing how dopamine—commonly known as the “feel-good” neurotransmitter—not only signals danger, but actively helps the brain unlearn fear. The findings, reported this week in the Proceedings of the National Academy of Sciences, could revolutionize potential treatments for anxiety disorders and post-traumatic stress disorder (PTSD), providing hope for millions worldwide—including those struggling in Thailand with trauma-related conditions (SciTechDaily).

A recent article published by HuffPost has shed new light on habits doctors warn everyone to avoid to dramatically reduce the risk of stroke — a disease that remains a silent but deadly threat worldwide, including in Thailand. Leading neurologists shared insights on seven lifestyle choices that can silently elevate stroke risk, and urge the public to make proactive changes for healthy brains and bodies throughout life. With strokes still ranking among the top causes of death and disability, preventive measures have never been more essential for Thai society.

A groundbreaking study published in the Journal of Physiology has revealed a remarkable connection between the liver and the brain, suggesting that ketones produced by the liver—especially during exercise—play a key role in keeping the brain healthy and maintaining memory function. The latest research, conducted by a team from the University of Missouri, shows that when the liver’s ability to produce ketones is blocked, rats experience memory deficits and diminished brain mitochondrial function, but that regular endurance training can effectively reverse these cognitive problems, even when ketone production is hampered (psypost.org).

A new Harvard-led study offers a glimmer of hope in Alzheimer’s care. The researchers suggest that a rigorous, multi-faceted lifestyle program may slow, and in some cases partially reverse, cognitive decline in early-stage patients. While preliminary and not definitive, the results invite a rethinking of non-drug approaches to dementia, with potential relevance for Thailand’s aging population.

In a 20-week trial published in Alzheimer’s Research & Therapy, 51 participants with an average age around 73.5 were studied. The intervention group included 26 individuals who followed an intensive plan: a strict plant-based diet with home-delivered meals, daily aerobic and strength training, targeted supplements, mindfulness practices, and weekly group support via online sessions. This “everything-in-one” approach required about 12 hours of guided activities each week and was designed to be highly supportive, including involvement from participants and their spouses. The study’s intensity is notable, as most prior dementia research has tested far less demanding programs.

A new study in the Journal of Physiology reveals a strong connection between the liver and the brain. Liver-produced ketones, especially during exercise, appear to support brain health and memory. In rats, hindering the liver’s ketone production led to memory deficits and reduced brain mitochondrial function, while sustained endurance training reversed these effects even when ketone production was impaired. These findings come from researchers at a major U.S. university and were summarized by PsyPost.

In a development that could shift global approaches to Alzheimer’s care, a recent study led by Harvard University and partners reports that intensive lifestyle interventions may not only slow but also partially reverse cognitive decline in some early-stage Alzheimer’s patients. While the findings are preliminary and warrant caution, they challenge long-standing assumptions about the irreversibility of one of the world’s most devastating neurodegenerative diseases and offer a spark of hope—especially for Thailand, where the rapidly aging population faces rising rates of dementia (Harvard Gazette, Local12.com, BGR).

A new international study shows that mammals with larger brains and stronger immune systems tend to live significantly longer. Researchers mapped the genomes of 46 species and found that brain size and expansive immune-related gene families are closely tied to maximum lifespans. While published in Scientific Reports, the work also offers timely insights for human health and aging, a topic of growing importance in Thailand as the country emphasizes preventive care and active aging.

A recent international study shines a light on a curious brain phenomenon called jamais vu. This condition makes familiar moments feel uncanny or entirely unfamiliar, even though we logically know them well. Seen as the opposite of déjà vu, jamais vu highlights how memory and perception can briefly misfire. The finding has potential implications for understanding everyday cognitive lapses and neurological health, with relevance for Thai readers navigating busy, modern lives.

A groundbreaking study has revealed that mammals with larger brains and more robust immune systems tend to live significantly longer lives. The international research team, spearheaded by the University of Bath and published in Scientific Reports, mapped the genomes of 46 mammalian species and discovered that both brain size and an expanded set of immune-related genes are strongly linked to each species’ maximum recorded lifespan. This scientific breakthrough does not just add a new chapter to our understanding of animal longevity; it also prompts intriguing implications for human health and aging—topics that resonate deeply with Thai society where active aging and preventive healthcare are becoming pillars of national policy.

In a compelling research development that is capturing international attention, scientists have identified a curious brain phenomenon known as “jamais vu”—a glitch that abruptly makes familiar situations appear completely strange, leaving millions feeling confused and disoriented in an instant. This startling effect, described as the psychological opposite of the well-known déjà vu, is gaining recognition for its implications on our understanding of memory, cognition, and neurological health. The revelation, recently featured in a widely discussed study, could significantly reshape the way we think about routine memory lapses and cognitive disturbances in daily life, including those experienced by people across Thailand.

A new study in Nature Reviews Neuroscience shows the brain does more than listen to music. It physically resonates with musical rhythms, shaping emotions, movement, and learning. This finding could transform neurological therapy, music education, and even how we design AI that understands human emotion. For Thailand, with music woven into temples, markets, schools, and festivals, the implications are especially meaningful.

In this research, a concept called Neural Resonance Theory (NRT) describes how the brain’s natural neural oscillations synchronize in real time with external music. Rather than simply predicting what comes next, the brain aligns its rhythms with beat, melody, and harmony. As a result, listening becomes a whole-body experience where perception, emotion, and movement are interconnected.

A new study sheds light on why certain people find it particularly difficult to follow conversations in noisy environments, identifying changes in a vital brain region known as the insula. Published this week in the journal Brain and Language, the research from the University at Buffalo shows that the left insula in individuals who struggle with “speech-in-noise” tasks works harder and displays altered connectivity—even when the brain is supposedly at rest—possibly explaining persistent listening difficulties as well as links to cognitive decline and dementia (Neuroscience News).

A groundbreaking new study published in Nature Reviews Neuroscience has revealed that our experience of music goes far beyond mere listening — the human brain and body physically resonate with musical rhythms in a way that shapes everything from emotional states to bodily movement. The discovery is poised to transform fields as diverse as neurological therapy, music education, and even artificial intelligence, with implications that reach right into daily life and the vibrant cultural landscape of Thailand.