#Brainhealth

People with biologically “young” brains can expect to outlive their peers with “old” brains, according to groundbreaking research released by Stanford Medicine. The study, published in the prestigious journal Nature Medicine on July 9, offers the most comprehensive evidence to date that the biological age of individual organs—especially the brain—is a powerful predictor of health outcomes and lifespan. This discovery opens new possibilities for early intervention and preventive medicine, potentially transforming how Thais approach aging-related diseases such as dementia and heart disease.

A groundbreaking study from Stanford Medicine shows that people with biologically “younger” brains tend to live longer and healthier lives. Published in Nature Medicine, the research provides strong evidence that the biological age of organs, especially the brain, predicts health outcomes and lifespan. The findings offer new avenues for early interventions and preventive care, with potential relevance for aging-related diseases in Thailand.

Involving nearly 45,000 participants from the UK Biobank, researchers followed health outcomes over 17 years. They measured nearly 3,000 proteins in blood samples to estimate organ-specific biological ages, including the brain, heart, lungs, kidneys, and liver. These protein patterns were compared with age-matched norms to classify organs as “extremely aged” or “extremely youthful.”

A new study suggests that a ketogenic diet—a high-fat, low-carbohydrate eating pattern—may improve brain health. The research reports a 22% increase in cerebral blood flow and a 47% rise in brain-derived neurotrophic factor (BDNF). These findings come as Thailand faces rising concerns about dementia and stroke amid an aging population.

For many Thai families, cognitive decline is a pressing worry. While the study details are still being shared, experts highlight a key takeaway: diet can influence neurological health in adults. A senior neurologist at a major regional hospital in Thailand notes that higher BDNF levels are encouraging because they’re linked to greater neural resilience, which could delay neurodegenerative diseases such as Alzheimer’s.

A groundbreaking new study has found that following a ketogenic diet can dramatically enhance brain health, increasing cerebral blood flow by 22% and boosting levels of a key brain growth factor, BDNF, by 47%. These impressive findings, originally reported by PsyPost, are sparking renewed interest in the potential of diet-based interventions to support cognitive function and prevent neurological disorders—a topic of immense interest to Thai readers, where concerns over dementia and stroke continue to rise.

For many Thais, it’s a familiar refrain heard from elders: “Each year passes faster than the last.” This shared experience, long chalked up to nostalgia or busy lives, now has new scientific backing. Recent research published in the journal European Review and summarized in an Earth.com article explains why our perception of time truly seems to speed up with age, lending insight into both the mechanics of the brain and possible ways for everyone, young or old, to reclaim a sense of fuller, richer days (Earth.com).

A growing body of scientific research is positioning spermidine—a naturally occurring compound found in certain foods and within the human body—as a potential “Swiss army knife of longevity,” offering wide-ranging benefits from heart and brain health to hair growth and immune support. The latest synthesis of this trend, highlighted in a recent piece from the New York Post, explores emerging evidence on spermidine’s ability to slow aging, support hormone balance, and promote healthier hair and internal organs, drawing intense interest among scientists, clinicians, and health-conscious citizens globally—including in Thailand.

Spermidine is a natural compound found in foods and the human body. It is gaining attention as a potential booster for healthy aging. Early evidence points to benefits for heart and brain health, hair vitality, and immune function. Researchers are examining how spermidine may slow aging processes and influence hormonal balance. The conversation is growing in Thailand as the population ages and chronic diseases rise.

For Thai readers, understanding spermidine matters. Thailand is facing increasing rates of diabetes, heart disease, and neurodegenerative conditions. Health authorities and communities seek practical, preventive approaches that fit Thai lifestyles. Spermidine could become part of everyday choices, alongside traditional wellness practices and a growing interest in functional foods and dietary supplements.

A new study from Karolinska Institute in Stockholm provides fresh evidence that the adult brain can generate new neurons, even in old age. Published in Science, the findings challenge the belief that brain growth ends in childhood and open doors to potential treatments for neurological and mental health conditions. For Thai readers, the research highlights implications for dementia, stroke recovery, and lifelong learning in an aging society.

Researchers examined brain tissue from 46 individuals aged from infancy to 78 years, using advanced single-cell genomics. They focused on the hippocampus, a region essential for memory and learning, and found neural progenitor cells actively dividing in adulthood alongside mature neurons. The results align with animal studies that have long shown adult stem cells in the brain.

A groundbreaking study from Sweden has provided compelling evidence that the adult human brain continues to generate new neurons well into old age, debunking the long-standing belief that brain cell growth halts after childhood. This discovery, published in the journal Science and highlighted in a recent Gizmodo report, offers new hope for future treatments of neurological and psychological disorders, and reshapes our understanding of the brain’s lifelong potential.

For decades, it was widely believed—taught both in schools and medical textbooks—that the human brain reached its full complement of neurons in early life, and that no new neurons were formed past childhood. While previous studies hinted at ongoing brain cell growth, scientific opinion remained split, with some researchers finding scant evidence for adult neurogenesis and others reporting clear signs. The confusion was particularly acute when it came to humans, since much of the existing evidence came from studies in animals such as mice or pigs.

A recent study shows that people who dislike exercise can rewire their brains to tolerate and even enjoy physical activity. Using neuroscience and psychology, researchers found that the brain’s response to discomfort can be gradually recalibrated, making regular activity more appealing and sustainable for sedentary individuals. Small, controlled bursts of physical stress shift how effort is perceived, creating a more positive exercise experience.

For Thailand, urban life, long work hours, and screen time contribute to inactivity. With rising non-communicable diseases, understanding how to weave movement into daily routines is crucial for personal health and national goals. The research offers a practical path: retrain the brain’s response to effort so exercise feels less daunting, rather than pushing through pain alone.

The explosive rise in popularity of AI-powered chatbots such as ChatGPT is sparking rigorous new research into how these digital assistants may be fundamentally altering the way our brains work. As Thai students, professionals, and families increasingly turn to generative AI for tasks ranging from essay writing to bedtime stories, urgent questions are emerging about whether this convenience comes with hidden cognitive costs.

For Thais who have rapidly adopted generative AI in education and everyday life, this inquiry has special relevance. Thailand’s government and universities have promoted digital literacy and the integration of AI in classrooms, aiming to boost competitiveness in the regional economy. Yet concerns are growing: is this powerful technology sharpening our minds, or is it making us passive consumers of machine-generated knowledge?

A groundbreaking study published in June 2025 is reshaping the way we think about physical activity, revealing that even those who “hate” exercise can train their brains to not only tolerate but actually enjoy working out. By leveraging the latest neuroscience and psychological techniques, researchers have demonstrated that our mental resistance to physical discomfort can be gradually recalibrated, making regular exercise more appealing and sustainable—even for the most sedentary individuals (SciTechDaily).

A new line of research suggests a gene-targeting approach could mimic the brain-protective effects of exercise, offering potential dementia prevention for Thailand’s aging population. The therapy targets pathways activated by physical activity, potentially helping elderly individuals who cannot engage in regular exercise due to mobility issues or advanced symptoms.

Thailand is undergoing a rapid demographic shift, with millions entering older age in the coming decade. Alzheimer’s disease and cognitive decline strain families, healthcare systems, and the broader economy. While exercise remains a cornerstone of brain health, many Thai seniors face barriers such as arthritis, chronic conditions, or limited access to fitness facilities.

A groundbreaking study from Harvard researchers has highlighted a novel approach to fighting cognitive decline associated with Alzheimer’s disease—one that does not require physical exertion but instead targets specific genes in the brain to replicate the beneficial effects of exercise. This research opens new avenues for treatments, particularly for those unable to engage in regular physical activity due to frailty or advanced symptoms.

Cognitive decline and Alzheimer’s disease remain pressing public health challenges globally, including in Thailand where a rapidly aging society faces rising rates of dementia. Traditionally, regular physical activity such as aerobic exercise has been strongly linked to slower cognitive deterioration and improved brain health. However, as experts note, many elderly patients—especially in the later stages of cognitive disorders—find it increasingly difficult to maintain an active lifestyle. This reality has driven scientists to explore the genetic and molecular pathways triggered by exercise, aiming to offer the same neuroprotective benefits via medical interventions.

In a promising turn for Alzheimer’s disease research, scientists at Harvard Medical School and Massachusetts General Hospital have identified a gene activated during physical exercise that could be targeted to slow cognitive decline in patients unable to exercise. This discovery, detailed in a recent study published in Nature Neuroscience, could pave the way for drug therapies that replicate the brain-boosting effects of exercise—offering renewed hope for millions, including Thailand’s rapidly aging population, at risk of dementia and related conditions.

Canned fatty fish like sardines and wild-caught salmon are gaining recognition for supporting cognitive function and potentially lowering dementia risk. For Thailand’s aging society, this budget-friendly staple offers a practical way to enhance nutrition without straining household budgets.

Regular, moderate consumption of omega-3 rich canned fish can help maintain brain health. These nutrients, particularly EPA and DHA, play a role in brain tissue and neuronal function. Public health professionals in Thailand emphasize that small, consistent dietary choices can contribute to healthier aging.

A new wave of scientific consensus is putting a humble pantry staple under the spotlight: canned fatty fish, such as sardines and wild-caught salmon, are being hailed by registered dietitians and researchers as the number one food for brain health according to a recent feature in Today.com (today.com). This accessible, budget-friendly ingredient, already familiar to many Thai households, is rapidly gaining recognition for its powerful effects in supporting cognitive function and reducing the risk of dementia—an insight with wide-ranging implications for Thailand’s aging society.

A new study from Harvard Medical School and Massachusetts General Hospital highlights ATPPIF1, a brain gene activated by exercise that may slow cognitive decline in Alzheimer’s patients who cannot exercise. Published in Nature Neuroscience, the findings suggest potential drugs or gene therapies that mimic exercise’s brain benefits. The discovery is particularly relevant for Thailand’s aging population.

For years, researchers have shown that physical activity can slow cognitive decline in Alzheimer’s and related dementias. But many patients, especially those with frailty or advanced disease, cannot exercise. The study addresses this gap by uncovering molecular pathways that exercise influences, pointing to interventions that stimulate these pathways directly in the brain.

A newly published analysis in The Economist revisits the decades-long debate on whether being bilingual actually benefits the brain, challenging long-held assumptions while highlighting persistent scientific uncertainty. With Thailand’s education system increasingly promoting English and Mandarin alongside Thai, the study’s findings carry particular weight for Thai families, educators, and policymakers contemplating the cognitive worth of learning an additional language.

For years, researchers have claimed that speaking two or more languages confers a host of cognitive advantages beyond mere linguistic prowess. In addition to opening doors to different cultural and professional opportunities, multilingualism has frequently been linked to improvements in “executive function”—an umbrella term covering skills like ignoring distractions, planning complex tasks, and adjusting one’s thinking as circumstances change. Widespread media coverage and popular science books have further fuelled the belief that bilingualism may even delay dementia, with some research suggesting bilinguals can experience the onset of dementia as much as four years later than monolinguals (The Economist).

A new analysis in The Economist revisits the long-standing question of whether bilingualism truly benefits the brain, and it cautions that the science remains uncertain. As Thailand expands English and Mandarin programmes alongside Thai, families, educators, and policymakers are paying close attention to what language learning actually delivers for cognitive health and learning outcomes.

For years, researchers have linked multilingualism to advantages beyond language—especially in executive function, which includes staying focused, planning tasks, and adapting to new rules. Media attention and popular science have bolstered the belief that bilingualism could delay dementia, with some studies suggesting bilinguals experience dementia onset several years later than monolingual peers. In Thailand, where many students enroll in English or Mandarin programmes and even trilingual international schools, residents have hoped language learning will sharpen thinking and problem-solving to drive the country’s development.

A new wave of neuroscience research is overturning long-held notions about the amount of physical activity needed for meaningful brain benefits. According to renowned neuroscientist and expert in brain plasticity, even just ten minutes of walking can prompt remarkable improvements in mood and cognition, effectively giving the brain a neurochemical “bubble bath” that rejuvenates mental health and function. This discovery is especially significant for busy Thais who struggle to dedicate time for lengthy exercise routines, suggesting that modest, regular physical movement could have a disproportionately positive impact on mental well-being.

New research is reshaping the view that thinking remains sharp only in youth. For Thais approaching midlife and beyond, evidence suggests daily choices—not luck or genes—drive cognitive health, memory, and social contribution throughout aging.

Thailand faces rapid growth in its elderly population, making healthy aging a national priority. In 2022, Thailand officially became an aged society with more than 20% of people over 60. This shift heightens concern about dementia, caregiver burden, and healthcare costs, while underscoring the need for practical, culturally resonant strategies to support older adults.

Groundbreaking neuroscience research published in the journal Psychopharmacology has revealed that individuals living with major depressive disorder show significantly lower levels of the antioxidant glutathione in the occipital cortex of the brain. This finding adds to a growing body of evidence suggesting that oxidative stress—including the subtle imbalance between damaging free radicals and the brain’s protective antioxidants—may be at the heart of depression’s complex biology (PsyPost).

This discovery is particularly meaningful in Thailand, where depression is becoming more widely recognized and discussed, yet biological risk factors remain less understood among the public. Mental health issues, including depression, are prevalent in the country, affecting individuals across various backgrounds, and contribute to personal suffering, economic loss, and significant stigma. Understanding the underlying biology of depression is thus not just academically interesting, but also a potential key to more effective prevention and treatment in Thai society.

A large meta-analysis in the field of neuroscience finds that individuals with major depressive disorder have significantly lower levels of the brain’s primary antioxidant, glutathione, in the occipital cortex. The study adds to growing evidence that oxidative stress plays a role in depression’s complex biology. In Thailand, where public understanding of mental health is expanding, these insights may help reduce stigma and improve prevention and treatment strategies.

The analysis pooled data from eight studies that used proton magnetic resonance spectroscopy to measure glutathione in living participants. The sample included 230 individuals diagnosed with major depressive disorder and 216 healthy controls. Researchers focused on two brain regions: the occipital cortex, important for visual processing, and the medial frontal cortex, linked to emotion and decision-making.