#Brainresearch

In a scientific breakthrough once thought impossible, an international team of researchers has created the first detailed three-dimensional map of a mammal’s brain, offering an unprecedented window into the structure and function of the mind. This ambitious feat, achieved by studying a tiny fragment of a mouse’s visual cortex, marks a pivotal advance in neuroscience and holds profound implications for understanding brain diseases such as Alzheimer’s and autism (CNN/Yahoo! News).

A groundbreaking international study has pinpointed a specific region in the brain responsible for deciding how generous we are with friends versus strangers. Researchers from Germany and South Africa have discovered that damage to the basolateral amygdala (BLA) sharply reduces our willingness to share with anyone outside our closest social circle—while generosity toward close friends stays intact. The findings, published recently in the Proceedings of the National Academy of Sciences, offer intriguing new insights into the biological roots of kindness and selfishness, and may have implications for understanding social disorders.

A wave of research is reshaping the way we understand ideology—not just as a social or political phenomenon, but as a deeply rooted function of the human brain. A recent book by political neuroscientist Dr. Leor Zmigrod, “The Ideological Brain: The Radical Science of Flexible Thinking,” has captured global attention by revealing how our biological wiring underpins not only our convictions but also our openness—or resistance—to evidence and change (Nautilus, NY Times). Why does ideology “taste” so good to the mind, and what makes some of us more likely to become deeply entrenched, even to the point of dogma? The answers emerging from neuroscience offer insight for Thais grappling with political polarization and social change.

A groundbreaking study from MIT is shaking up decades of neuroscience wisdom, revealing the brain’s “object recognition” pathway may also play a significant role in understanding spatial information—an insight that could revolutionize our approach to learning, artificial intelligence, and brain health around the world, including here in Thailand.

For years, scientists have believed the ventral visual stream, a key pathway in the human brain, is dedicated to recognizing objects—like a Starbucks cup on a Bangkok Skytrain or a rambutan vendor at the Chatuchak Market. This idea shaped not just neuroscience textbooks, but also inspired computer vision systems now used in everything from smartphones to smart cars. Yet, new research led by MIT graduate student Yudi Xie suggests the story is far more nuanced. Their findings, presented at the prestigious International Conference on Learning Representations, show that when deep learning models are trained not only to identify objects, but also to understand spatial features like location, rotation, and size, these models mirror neural activity in the ventral stream just as accurately as traditional object recognition models. In other words, the ventral stream might be wired for much more than recognizing faces or products—it could be a multifaceted toolkit for seeing and interacting with the world.

In a scientific feat once thought to border on the impossible, a global team of researchers has produced the first-ever hyper-detailed, three-dimensional map of a mammalian brain, marking a significant leap forward in neuroscience. Using just a tiny speck of mouse brain matter—the size of a grain of sand—scientists at the Allen Institute for Brain Science, Baylor College of Medicine, and Princeton University meticulously mapped out the intricate web of 84,000 neurons and over 500 million synapses within a cubic millimeter of tissue. This digital reconstruction, now published in the journal Nature, is being hailed as the most comprehensive mammalian brain map ever generated, fueling optimism for breakthroughs in understanding brain disorders such as Alzheimer’s, Parkinson’s, autism, and schizophrenia (CNN).

Recent research into the brain’s natural mechanisms for managing pain reveals fascinating insights that could revolutionize the way we approach pain management. At the heart of this discovery is the periaqueductal grey (PAG), a brain region that plays a crucial role in suppressing pain even before it reaches our conscious awareness. This study explains why individuals with severe injuries, such as soldiers during WWII, sometimes feel little to no pain and opens potential pathways for non-opioid pain therapies.

In a significant leap toward understanding brain communication, researchers at Johns Hopkins Medicine have harnessed cutting-edge cryo-electron microscopy (cryo-EM) to reveal how glutamate, a key neurotransmitter, activates brain channels. This discovery not only deepens our understanding of neural communication processes but also paves the way for novel treatments for neurological conditions like epilepsy and specific intellectual disabilities source.

The ability of our brains to engage with the environment and learn is fundamentally dependent on the chemical interplay between neurons. At the heart of this communication network is glutamate, a neurotransmitter that binds to AMPA receptors, triggering electrical signals that pass through neurons like messages along a bustling Thai street during rush hour. This study, spearheaded by Johns Hopkins researchers in collaboration with UTHealth Houston scientists, was recently published in the esteemed journal Nature.

Recent groundbreaking research from MIT and Harvard University reveals a fascinating intersection between the immune and nervous systems that may redefine our understanding of illness and behavior. Immune molecules, known as cytokines, have long been recognized for their role in fighting infections; however, these studies unveiled their significant impact on the brain, influencing emotions such as anxiety and sociability. This new insight could have profound implications for treating a range of neurological conditions, including autism and depression.

In a groundbreaking study published recently, scientists from Johns Hopkins Medicine have employed advanced cryo-electron microscopy (cryo-EM) to illuminate how glutamate—a key neurotransmitter in the brain—interacts with AMPA receptors. This research, conducted in collaboration with UTHealth Houston and funded by the National Institutes of Health, unlocks new potential pathways for treating neurological conditions such as epilepsy and certain intellectual disabilities. Using this specialized imaging technique, the team has captured molecular-level details of how brain receptors function, providing crucial insights that could drive the development of new therapeutic drugs.

Scientists have unlocked a deeper understanding of brain communication thanks to groundbreaking advancements in microscopy. By visualizing how glutamate, a key neurotransmitter, activates brain receptors, researchers are paving the way for new treatments for neurological conditions like epilepsy and intellectual disabilities. This pioneering study, recently published in the journal Nature, showcases how this critical brain process occurs at the molecular level.

In this innovative research spearheaded by Johns Hopkins Medicine, alongside collaborators from UTHealth Houston, scientists employed a cutting-edge cryo-electron microscope (cryo-EM) to capture high-resolution images of glutamate in action. The study illuminates the intricate dance between glutamate and AMPA receptors, channels which play a vital role in neuron-to-neuron communication—a fundamental aspect of how we perceive our environment and learn. Edward Twomey, Ph.D., a key researcher in the study, highlights that neurons’ ability to communicate through chemical signals is foundational for brain function.

In an intriguing development, scientists are uncovering the intricate workings of the brain that signal when we need to eat or drink. A recent study conducted by the Max Planck Institute for Biological Intelligence, in collaboration with the University of Regensburg and Stanford University, has found critical insights into how specific neurons within the brain’s amygdala may drive our basic urges to eat and drink. This discovery not only adds depth to our understanding of these essential functions but also opens new avenues for tackling conditions like obesity, anorexia, and even addiction.