#Chemistry

In a scientific breakthrough decades in the making, researchers have finally confirmed a “crazy” theory dating back to 1958 involving vitamin B1, or thiamine. By successfully stabilizing an extremely reactive molecule known as a carbene in water—something scientists long believed to be impossible—this team has not only resolved a long-standing biochemical debate but also unlocked new possibilities for sustainable chemical manufacturing around the world, including Thailand. Their results, published in Science Advances on April 11, 2025, have sparked fresh excitement in both academic and industrial laboratories worldwide (SciTechDaily).

In a major development that could transform both medicine and nutrition science, a team of chemists has successfully confirmed a decades-old theory regarding vitamin B1 (thiamine) — a feat once considered impossible. Their findings, detailed in recent reports, promise to sharpen understanding of how this vital nutrient functions at the molecular level, potentially opening new avenues for treating diseases and improving public health policy worldwide.

The breakthrough centers on the molecular mechanisms underpinning the biological activity of vitamin B1, a nutrient essential for nerve, muscle, and heart function. For years, scientists suspected that thiamine played a more sophisticated role within the body’s metabolic processes than previously confirmed, but technical barriers made it nearly impossible to observe and verify those processes in detail. The research team, leveraging advanced analytical techniques and state-of-the-art laboratory tools, have now provided the first direct evidence that supports these long-standing theories, upending conventional wisdom and energizing researchers around the globe.