#Cognitive Function

In a groundbreaking study, scientists at Columbia University and the University of Bordeaux have produced a detailed atlas of mitochondria, the energy powerhouses, across various regions of the human brain. Utilizing a novel method involving slicing a frozen human brain into 703 cubes, each the size of a sugar cube, researchers have mapped how these minuscule engines are distributed and function. This venture, known as MitoBrainMap, is poised to open new avenues in understanding and potentially treating conditions such as depression and Alzheimer’s disease, two major health concerns worldwide, including in Thailand.

A groundbreaking study has unveiled a detailed atlas of the brain’s mitochondria, revealing that areas responsible for higher cognitive functions are equipped with more energy resources. Conducted by researchers at Columbia University, this study provides critical insights into how mitochondrial distribution and specialization affect brain health and disease. Understanding these energy dynamics opens new doors for exploring the origins of neurodegenerative and neuropsychiatric disorders, which offer potential pathways for innovative treatments.

In recent years, creatine has gained attention beyond the typical weightlifting community, now attracting interest from women, particularly those in midlife, looking for its manifold benefits. Traditionally known for its muscle-enhancing properties, creatine supplementation is now being explored for its cognitive and overall health benefits, making it a potentially valuable addition for Thai women navigating the complexities of aging.

Creatine, a compound naturally produced in the body, plays a crucial role in creating ATP, the primary energy molecule utilized by muscle and brain tissues. While the body synthesizes creatine, the amount is often insufficient for individuals engaging in rigorous physical activity or experiencing age-related muscle decline. Thus, many are turning to supplements to bridge this gap, especially as creatine is mainly found in animal products like red meat, which may not be consumed in sufficient quantities to harness its full benefits. Recent research supports creatine’s ability to enhance muscle mass by allowing individuals to exert more energy during physical activities, thereby promoting better muscle growth and faster recovery. However, the benefits of creatine extend beyond the gym.

In recent years, creatine—a supplement traditionally linked to bodybuilding—has been gaining traction among middle-aged women as a potential ally for both physical and cognitive well-being. This trend, as explored in a feature by Oprah Daily, highlights how a supplement favored by fitness enthusiasts is now capturing the attention of a broader demographic. Featuring testimonials from women who experience enhanced muscle strength and reduced brain fog, the article suggests that creatine could become a staple for Thai women approaching menopause, a transition often marked by similar concerns.

A groundbreaking pilot study has unveiled a fascinating aspect of human endurance, where during prolonged strenuous exercise like marathons, the brain might begin to ’eat’ itself by consuming its fatty sheath—myelin—for fuel. This unexpected finding adds a novel layer to our understanding of neuroplasticity, showcasing a radical adaptation strategy when glucose levels in the brain plummet.

The study, conducted by neuroscientists in Spain, involved 10 marathon runners who underwent MRI scans before and after their races. It was observed that 24 to 48 hours following the grueling 42-kilometer run, there was a significant reduction in myelin levels within regions of the brain crucial for motor skills, coordination, sensory, and emotional processing. Fortunately, these changes were not permanent. Just two weeks after the race, the myelin levels began to recuperate, and a full recovery was noted in most participants within two months.