#CognitiveScience

In a significant leap toward understanding brain communication, researchers at Johns Hopkins Medicine have harnessed cutting-edge cryo-electron microscopy (cryo-EM) to reveal how glutamate, a key neurotransmitter, activates brain channels. This discovery not only deepens our understanding of neural communication processes but also paves the way for novel treatments for neurological conditions like epilepsy and specific intellectual disabilities source.

The ability of our brains to engage with the environment and learn is fundamentally dependent on the chemical interplay between neurons. At the heart of this communication network is glutamate, a neurotransmitter that binds to AMPA receptors, triggering electrical signals that pass through neurons like messages along a bustling Thai street during rush hour. This study, spearheaded by Johns Hopkins researchers in collaboration with UTHealth Houston scientists, was recently published in the esteemed journal Nature.

In a significant advancement for neuroscience, researchers have unveiled new insights into how the human brain creates and retrieves memories. The research, led by Dr. Tomás Ryan at Trinity College Dublin, highlights the pivotal role of “engram cells”—a group of neurons that capture and store experiences through their connections. This discovery represents a paradigm shift from traditional views that memories reside within individual neurons. Instead, the focus is now on the dynamic and structural connections between these neurons, potentially transforming how we understand memory processing.

In a pioneering study, researchers from UC Santa Cruz and UC San Francisco have overturned traditional neuroscientific tenets by demonstrating that neurons, the cellular pillars of brain activity, exhibit far greater plasticity than previously acknowledged. Published in the journal iScience, this research unveils the startling ability of certain neurons to transform type in response to their environment, a finding that could revolutionize our understanding of brain functions and neurodevelopmental disorders (Source).