#Depression

A new review from researchers in the United Kingdom has highlighted four dietary supplements—St. John’s wort, probiotics, vitamin D, and saffron—that present the strongest evidence for easing depressive symptoms, according to an analysis published this week in Health.com (health.com). The study, which assessed hundreds of clinical trials covering 64 different over-the-counter supplements, arrives as Thailand and the world see surging interest in self-care for mental wellbeing amid persistent stigma around psychiatric treatment.

Groundbreaking research into psychedelic compounds is shedding new light on how these substances might revolutionize the treatment of mental health disorders, promising innovative alternatives for people in Thailand and across the globe. A suite of recent studies explores the biological and psychological mechanisms by which psychedelics—including psilocybin (found in magic mushrooms), lysergic acid diethylamide (LSD), ayahuasca, and MDMA—modulate brain circuits, emotions, and cognition with potentially enduring therapeutic benefits. These advances herald a growing shift from anecdotal and early-phase examinations of psychedelics toward a more rigorous, mechanistic understanding crucial for clinical application.

A newly published review in JAMA Psychiatry has sparked controversy among mental health experts, raising concerns that it significantly underestimates the risks faced by long-term users of antidepressants when they attempt to discontinue their medication. The debate centers on the review’s focus on short-term, industry-funded studies and has important implications for millions worldwide, including a growing cohort of patients in Thailand who rely on antidepressant therapy.

Antidepressant withdrawal — the range of physical and psychological symptoms experienced when stopping or reducing dosage — has come under increased scrutiny as more people use these medications for extended periods. While previous medical guidelines, such as those from the UK’s National Institute for Health and Care Excellence (NICE), described withdrawal as “brief and mild,” recent scrutiny has revealed a more complex picture, particularly for long-term users. The new JAMA Psychiatry review, authored in part by academics with ties to pharmaceutical companies, concludes that withdrawal symptoms from antidepressants are generally not clinically significant for most users, especially those on the medication for only eight to twelve weeks. Its analysis, based on eleven trials — the vast majority of which involved short-term use — found slightly more withdrawal symptoms in those stopping antidepressants than in placebo groups, but the authors attribute much of this to the “nocebo effect” (the power of negative expectations to trigger adverse symptoms) rather than to withdrawal itself.

As more research unravels the powerful influence of vitamin D — often dubbed the “sunshine vitamin” — fresh evidence illustrates just how critical this nutrient is for protecting against some of the most serious health conditions known today. While vitamin D is well-established as pivotal for bone health, new studies underscore its broader impacts on immunity, mental health, autoimmune diseases, and even cancer, raising public health alarms, especially in regions like Thailand where sun exposure is plenty, yet deficiencies surprise both doctors and public alike.

A recent study has found a notable association between skipping breakfast and elevated depressive symptoms among young people—a relationship that sheds new light on how daily routines may influence mental health. The research, conducted with over 3,000 Hong Kong youths and published in the journal Frontiers in Psychiatry, points to subtle yet measurable links between breakfast habits, impulsivity, and mental wellbeing, especially among those aged 15 to 24 (psypost.org).

Dieticians and mental health experts have long emphasized the importance of breakfast, but this study is one of the largest to specifically connect meal-skipping with psychological symptoms in Asian youth. For Thai readers, whose breakfast culture ranges from modest rice porridge to noodle soups and fried treats, these findings highlight the intersection between traditional eating habits and mental health—a subject growing in relevance as lifestyles become busier across Thailand.

As Thailand’s society becomes increasingly aware of mental health challenges, especially post-pandemic, many are grappling with the often unseen social costs of depression. Recent global research and lived experiences—like that described in Slate’s recent advice column about a decade-old friendship tested by one friend’s withdrawal and history of depression—highlight a growing dilemma: when a person’s struggle with a common illness like depression begins to erode the very bonds that once provided support and joy, what are friends to do? slate.com

A sweeping new study has found that rates of depression and severe psychological distress differ widely across job sectors, with employees in retail, food service, media, and healthcare support among the most at risk. The findings underscore the urgent need for tailored workplace mental health strategies, particularly as young adults and women are shown to be disproportionately affected.

The research, led by a team at the US Centers for Disease Control and Prevention’s National Institute for Occupational Safety and Health, analyzed data from over 536,000 working adults across 37 US states, collected between 2015 and 2019. The results, published in JAMA Network Open (JAMA Network Open, June 2025), paint a nuanced portrait of how occupation, age, gender, and insurance status shape mental well-being across the labor market. This information is particularly timely for Thailand, where the impacts of economic change, urbanization, and shifting industry are reshaping the workforce and its vulnerabilities.

New research published in eNeuro reveals how the human brain tracks and navigates rapid emotional transitions, using music to illuminate the shifting neural landscapes behind our changing moods. This discovery, which highlights the powerful influence of previous emotional states on subsequent emotional experiences, holds promise for informing future therapies for mood disorders such as depression—conditions characterized by difficulty in shifting out of negative emotional states.

In a world where music soundtracks everything from daily commutes to spiritual rituals, the news that our brains process emotional music based on recent experiences is both intuitively familiar and scientifically groundbreaking. Thai readers, whose relationship with music spans mor lam and luk thung to Western pop, may find these findings particularly resonant, linking the local appreciation of musical storytelling with new understandings of mental health.

A groundbreaking new study from the Japan Institute for Health Security has found that adults adhering to a traditional Japanese-style diet experience significantly lower rates of depressive symptoms. The research, the first of its kind conducted at this scale in Japan, could have important ramifications for public health and workplace mental wellness initiatives both in Thailand and worldwide.

The relevance of these findings is especially sharp for Thai readers. With depression rates steadily rising in Thailand and across Asia, understanding the role of diet in mental well-being may offer a practical and culturally adaptable path toward prevention. Modern Thai society, like Japan, is facing rapid urbanization, social isolation, and dietary shifts that impact both physical and mental health. As Thais increasingly adopt processed and Westernized eating habits, this new evidence spotlights the potential power of returning to traditional foodways.

New research is shedding light on a paradox long observed in entertainment and everyday life: some of the world’s funniest individuals also struggle with some of the deepest emotional pain. Recent findings compiled by a neuroscience expert in Psychology Today draw directly on brain science and psychological studies to explain this hidden connection, offering insights not only for global audiences but also for Thai readers who deeply value humor as a tool for social connection.

A startling new survey by the UK’s National Health Service (NHS) has found that one in four young people in England now lives with a mental health condition, highlighting a growing crisis that has implications far beyond British borders—including for Thailand’s youth. The figure, revealed this week, underscores mounting concerns among educators, policymakers, and medical professionals, as rates of depression, anxiety, and related disorders soar among adolescents. Mental health experts say the findings should serve as a wake-up call for countries worldwide, including Thailand, given the parallels in academic pressures, social media influence, and lingering effects of the COVID-19 pandemic.

Groundbreaking neuroscience research published in the journal Psychopharmacology has revealed that individuals living with major depressive disorder show significantly lower levels of the antioxidant glutathione in the occipital cortex of the brain. This finding adds to a growing body of evidence suggesting that oxidative stress—including the subtle imbalance between damaging free radicals and the brain’s protective antioxidants—may be at the heart of depression’s complex biology (PsyPost).

This discovery is particularly meaningful in Thailand, where depression is becoming more widely recognized and discussed, yet biological risk factors remain less understood among the public. Mental health issues, including depression, are prevalent in the country, affecting individuals across various backgrounds, and contribute to personal suffering, economic loss, and significant stigma. Understanding the underlying biology of depression is thus not just academically interesting, but also a potential key to more effective prevention and treatment in Thai society.

A new study led by the University of Edinburgh has found that children who struggle to manage their emotions as early as age seven are at a much higher risk of developing anxiety and depression during their teenage years. The research, published in the Journal of Affective Disorders and funded by the UK’s Medical Research Foundation, tracked nearly 19,000 young people and uncovered a clear connection between early difficulties with emotion regulation and later internalizing problems such as sadness, worry, and fear. The findings highlight the critical importance of teaching emotional coping skills in childhood—a lesson with profound implications for parents and educators in Thailand and around the world Neuroscience News.

A groundbreaking small study reported this week suggests that a single dose of psilocybin—the active compound in so-called “magic mushrooms”—may provide significant antidepressant effects that last at least five years for most patients. This finding, detailed in Live Science, could herald a new era in mental health treatment strategies, especially for those battling persistent depression.

The importance of this research resonates across the globe and holds particular interest for Thailand, where mental health care has experienced increased public attention and evolving social attitudes in recent years. Historically, treatment protocols for depression in Thailand have primarily relied on psychotherapy and long-term pharmacological interventions, yet many patients continue to suffer relapse or side effects. Emerging research on psychedelic-assisted therapy, such as this recent study, offers hope for more durable solutions and challenges existing stigmas surrounding mental health and controlled substances.

A single dose of psilocybin, the psychoactive compound found in so-called “magic mushrooms,” has been revealed in new research to offer substantial relief from depression that can last for at least five years in most patients, according to a small but significant study highlighted by LiveScience. The findings, while preliminary, add to a growing body of global evidence suggesting that psychedelic-assisted therapy might hold promise as a long-term treatment for major depressive disorder—an illness affecting millions worldwide, including many here in Thailand.

Recent research published in the Journal of Psychiatric Research has shed new light on the impact of low-carbohydrate diets on depression, revealing that not all low-carb approaches are created equal when it comes to mental health. The study found that adults who adhered to low-carb diets rich in plant-based proteins, unsaturated fats, and minimal refined carbohydrates were significantly less likely to report symptoms of depression. However, low-carb diets heavy in animal proteins and saturated fats did not confer the same mental health benefits, underlining the critical importance of diet quality — not just macronutrient ratios — for psychological well-being (PsyPost).

From yellow blooms gleaming in midsummer fields to bottles lining pharmacy shelves, St. John’s wort (Hypericum perforatum) has captured human fascination for centuries. Once considered a magical plant to ward off evil and heal the mind and body, today this humble wildflower sits at the intersection of folk medicine and rigorous clinical investigation. As health-conscious readers search for natural ways to support mental health, St. John’s wort stands as a classic example of how traditional botanical wisdom and modern science sometimes converge—and sometimes diverge—in the ongoing quest for well-being.

A surge of recent scientific findings is bringing fresh attention to an unexpected driver of mental health—our gut. Researchers are increasingly convinced that the trillions of microbes inhabiting our intestines may play a powerful and direct role in the development and persistence of depression, a discovery that could revolutionize approaches to mental wellness in Thailand and around the world. This “gut-brain axis” challenges longstanding beliefs about the origins of mood disorders and opens the possibility that treating depression could one day involve rebalancing our internal ecosystem just as much as managing brain chemistry.

A groundbreaking study led by researchers at the Hebrew University of Jerusalem has found that individuals with depressive symptoms are more likely to interpret neutral situations negatively when exposed to unrelated negative surroundings—a phenomenon described as an “emotional spillover” effect. This discovery carries significant implications for understanding and treating depression in Thailand, where mental health issues remain a deeply sensitive topic, and highlights new avenues for improving emotional resilience in a rapidly changing society (Neuroscience News).

Fresh research is shedding light on the surprising causes behind higher rates of depression among vegans—a phenomenon with ripples beyond just dietary choices, impacting careers, relationships, and the broader landscape of modern identity. While past debates have focused on nutrition and social pressures, new evidence points to deeper psychological roots that are relevant not just to plant-based eaters, but to anyone who closely identifies with rigid belief systems.

The recent discussion, sparked by a widely shared article in VegOut Magazine, captured the attention of global readers—including many who weren’t vegan at all. The piece, authored by a psychological observer based in Singapore, delved into research showing elevated rates of depression and anxiety in vegan populations. What emerged, however, was a hidden pattern that extended well beyond diet: a modern epidemic of “identity fusion,” where personal sense of self merges completely with group ideology, making beliefs feel inseparable from one’s core identity (VegOut Magazine).

A striking personal narrative recently emerged from Summit County, Colorado, challenging the prevailing belief that natural beauty and an active lifestyle insulate mountain town residents from mental health struggles. The story, reported by the Summit Daily, follows a young, passionate skier who relocated to the Rockies, only to find his depression relentless, immune to the distractions of slopes and alpine vistas. His candid account mirrors a rising tide of research showing that depression can follow individuals across geographical and social boundaries—and that mountain communities, often romanticized for their serenity, face unique mental health challenges.

A ground-breaking study involving nearly 20,000 individuals has revealed that persistent negative thoughts aren’t just distressing—they may also be physically altering the very structure and functioning of your brain. In research led by a team at Amen Clinics, a prominent US-based brain health diagnostics institution, scientists used brain scans and cognitive data from individuals diagnosed with anxiety disorders, discovering clear links between what is called the “negativity bias” and abnormal patterns in several critical brain regions. For Thai readers, this may shed new light on mental health struggles and introduces opportunities for science-backed practices to improve national wellbeing.

A pioneering study using eye-tracking technology has revealed that individuals with depression pay disproportionate attention to threatening and neutral images, potentially reinforcing the cycle of negative thinking characteristic of depressive disorders. The research, recently published in the Journal of Affective Disorders, sheds light on the subtle ways depression influences how people process the world around them—an insight with significant implications for clinical practice and daily life in Thailand and beyond (PsyPost).

A new scientific study has shed light on a persistent challenge faced by those experiencing anxiety and depression: the tendency to underestimate their own abilities even when objective evidence shows they are correct. The research, published in the esteemed journal Nature Communications, suggests that while anxious and depressed individuals perform as well as their peers, they struggle to internalize moments of success, leaving them prone to chronic underconfidence. This discovery could have significant implications for mental health awareness and treatment approaches in Thailand, where stigma and underdiagnosis of mental health issues remain widespread.