#Depression

A recent review in JAMA Psychiatry has reignited debate among mental health professionals about withdrawal risks for people who discontinue antidepressants, especially after extended use. This discussion is timely for Thailand, where more patients rely on long‑term therapy and guidelines continue to adapt to evolving evidence.

Antidepressant withdrawal involves a spectrum of physical and psychological symptoms that can occur when reducing or stopping medication. Earlier guidelines, including NICE in the UK, described withdrawal as brief and mild. Newer research paints a more nuanced picture, particularly for long‑term users. The JAMA Psychiatry review analyzed eleven trials, most of which examined short‑term use, and found slightly more withdrawal symptoms in those stopping antidepressants than in placebo groups. The authors attributed much of this to the nocebo effect—the power of negative expectations to trigger symptoms—rather than withdrawal itself.

Vitamin D, often called the sunshine vitamin, affects far more than bones. New studies highlight its role in immunity, mood, autoimmune conditions, and some cancers. In Thailand, open skies meet surprising deficiency rates. Urban living, indoor work, and pollution limit actual sun exposure, raising public health concerns.

Vitamin D is unique because skin synthesis relies on sunlight. It supports calcium absorption to keep bones strong. But persistent indoor lifestyles, changing diets, and air pollution can lower vitamin D levels, leaving populations vulnerable to multiple health issues. A synthesis of recent research links insufficient vitamin D with osteoporosis, depressive symptoms, autoimmune conditions, and certain cancers.

As more research unravels the powerful influence of vitamin D — often dubbed the “sunshine vitamin” — fresh evidence illustrates just how critical this nutrient is for protecting against some of the most serious health conditions known today. While vitamin D is well-established as pivotal for bone health, new studies underscore its broader impacts on immunity, mental health, autoimmune diseases, and even cancer, raising public health alarms, especially in regions like Thailand where sun exposure is plenty, yet deficiencies surprise both doctors and public alike.

A large study of more than 3,000 young people in Hong Kong reveals a notable link between skipping breakfast and higher depressive symptoms. The researchers tracked daily routines among youths aged 15 to 24 and found that breakfast skippers reported greater impulsivity and more pronounced depressive symptoms, while anxiety showed a weaker association.

Nutrition and mental health experts have long emphasized the value of a morning meal. This study is among the largest to connect breakfast habits with mental health indicators in Asian youths. For Thai readers, where breakfast stretches from rice porridge and noodle soups to fried snacks, the findings illuminate how traditional eating patterns interact with emotional well-being—an issue gaining urgency as busy lifestyles spread across Thailand.

A recent study has found a notable association between skipping breakfast and elevated depressive symptoms among young people—a relationship that sheds new light on how daily routines may influence mental health. The research, conducted with over 3,000 Hong Kong youths and published in the journal Frontiers in Psychiatry, points to subtle yet measurable links between breakfast habits, impulsivity, and mental wellbeing, especially among those aged 15 to 24 (psypost.org).

Dieticians and mental health experts have long emphasized the importance of breakfast, but this study is one of the largest to specifically connect meal-skipping with psychological symptoms in Asian youth. For Thai readers, whose breakfast culture ranges from modest rice porridge to noodle soups and fried treats, these findings highlight the intersection between traditional eating habits and mental health—a subject growing in relevance as lifestyles become busier across Thailand.

As Thailand’s society becomes increasingly aware of mental health challenges, especially post-pandemic, many are grappling with the often unseen social costs of depression. Recent global research and lived experiences—like that described in Slate’s recent advice column about a decade-old friendship tested by one friend’s withdrawal and history of depression—highlight a growing dilemma: when a person’s struggle with a common illness like depression begins to erode the very bonds that once provided support and joy, what are friends to do? slate.com

Depression changes how people connect, and in Thai communities it can strain long-standing friendships. A recent global reflection about a decade-old friendship tested by withdrawal highlights a common challenge: sustaining bonds when mental health reshapes interaction. The story reminds readers that depression is not just private pain; its effects ripple through social circles and test even the strongest relationships.

Depression alters social engagement. In the case discussed, one friend gradually stops meeting, stops replying, and becomes harder to reach. The narrative acknowledges the sadness and confusion friends feel and shows that withdrawal is both a symptom and a consequence of depression. For Thai readers, this points to the importance of recognizing early signs and offering steady, non-judgmental support.

A sweeping new study has found that rates of depression and severe psychological distress differ widely across job sectors, with employees in retail, food service, media, and healthcare support among the most at risk. The findings underscore the urgent need for tailored workplace mental health strategies, particularly as young adults and women are shown to be disproportionately affected.

The research, led by a team at the US Centers for Disease Control and Prevention’s National Institute for Occupational Safety and Health, analyzed data from over 536,000 working adults across 37 US states, collected between 2015 and 2019. The results, published in JAMA Network Open (JAMA Network Open, June 2025), paint a nuanced portrait of how occupation, age, gender, and insurance status shape mental well-being across the labor market. This information is particularly timely for Thailand, where the impacts of economic change, urbanization, and shifting industry are reshaping the workforce and its vulnerabilities.

A global study reveals that depression and serious psychological distress vary by job sector, with retail, food service, media, and healthcare support roles showing the highest risk. The findings underscore the need for sector-specific mental health programs, particularly as young adults and women are disproportionately affected. Data from more than 536,000 working adults across the United States informed the analysis, which examined how occupation, age, gender, and insurance status influence mental well-being. The insights are especially relevant for Thailand, where rapid economic shifts and urban growth are reshaping the workforce and its vulnerabilities. In Thailand, service and hospitality roles have expanded quickly, reflecting global patterns of stress in high-demand industries.

New research published in eNeuro reveals how the human brain tracks and navigates rapid emotional transitions, using music to illuminate the shifting neural landscapes behind our changing moods. This discovery, which highlights the powerful influence of previous emotional states on subsequent emotional experiences, holds promise for informing future therapies for mood disorders such as depression—conditions characterized by difficulty in shifting out of negative emotional states.

In a world where music soundtracks everything from daily commutes to spiritual rituals, the news that our brains process emotional music based on recent experiences is both intuitively familiar and scientifically groundbreaking. Thai readers, whose relationship with music spans mor lam and luk thung to Western pop, may find these findings particularly resonant, linking the local appreciation of musical storytelling with new understandings of mental health.

A new study reveals how the brain tracks emotional shifts through music, offering insights into mood regulation and potential therapies for mood disorders such as depression. The research shows that prior emotions influence how we experience upcoming feelings, highlighting opportunities to tailor interventions that ease negative states.

For Thai readers, music connects tradition with contemporary well-being. From mor lam and luk thung to international pop, music’s storytelling power mirrors everyday life and community healing, now supported by neuroscience.

A groundbreaking new study from the Japan Institute for Health Security has found that adults adhering to a traditional Japanese-style diet experience significantly lower rates of depressive symptoms. The research, the first of its kind conducted at this scale in Japan, could have important ramifications for public health and workplace mental wellness initiatives both in Thailand and worldwide.

The relevance of these findings is especially sharp for Thai readers. With depression rates steadily rising in Thailand and across Asia, understanding the role of diet in mental well-being may offer a practical and culturally adaptable path toward prevention. Modern Thai society, like Japan, is facing rapid urbanization, social isolation, and dietary shifts that impact both physical and mental health. As Thais increasingly adopt processed and Westernized eating habits, this new evidence spotlights the potential power of returning to traditional foodways.

A major study by the Japan Institute for Health Security shows that adults who follow a traditional Japanese-style diet report fewer depressive symptoms. This large-scale research marks a turning point in understanding how everyday eating patterns can influence mental health in both workplace and community settings.

For Thai readers, the findings offer timely relevance. Depression is rising in Thailand and across Asia, making practical dietary strategies increasingly appealing. Like Japan, Thai society is navigating urban living, social change, and evolving food habits. This study highlights the potential impact of returning to nutrient-rich, traditional foods in supporting mental well-being.

New research is shedding light on a paradox long observed in entertainment and everyday life: some of the world’s funniest individuals also struggle with some of the deepest emotional pain. Recent findings compiled by a neuroscience expert in Psychology Today draw directly on brain science and psychological studies to explain this hidden connection, offering insights not only for global audiences but also for Thai readers who deeply value humor as a tool for social connection.

New science is clarifying a paradox many have observed: some of the world’s funniest individuals also wrestle with deep emotional pain. A neuroscience-focused review in Psychology Today links brain science to the humor-emotion connection, offering insights relevant to Thai readers who value laughter as a social glue.

Thailand loves comedy, from Likay theatre and stand-up to TV satire. Jokes brighten markets, offices, and classrooms, yet research suggests making others smile can be both a blessing and a burden. A neuroscience piece notes that comedians and people with a talent for humor show complex brain activity. Laughter releases mood-boosting chemicals like dopamine and serotonin, providing momentary relief. For those with depression, the usual sources of pleasure can be disrupted, making humor a coping mechanism rather than mere entertainment.

A startling new survey by the UK’s National Health Service (NHS) has found that one in four young people in England now lives with a mental health condition, highlighting a growing crisis that has implications far beyond British borders—including for Thailand’s youth. The figure, revealed this week, underscores mounting concerns among educators, policymakers, and medical professionals, as rates of depression, anxiety, and related disorders soar among adolescents. Mental health experts say the findings should serve as a wake-up call for countries worldwide, including Thailand, given the parallels in academic pressures, social media influence, and lingering effects of the COVID-19 pandemic.

A new survey from England’s National Health Service reveals that one in four young people now lives with a mental health condition. The finding signals a growing youth mental health crisis with implications beyond Britain, including for Thailand. Educators, clinicians, and policymakers are closely watching as rates of depression, anxiety, and related disorders rise among teenagers. Experts say the lessons are global, given similar pressures from academics, online life, and lingering pandemic effects.

Groundbreaking neuroscience research published in the journal Psychopharmacology has revealed that individuals living with major depressive disorder show significantly lower levels of the antioxidant glutathione in the occipital cortex of the brain. This finding adds to a growing body of evidence suggesting that oxidative stress—including the subtle imbalance between damaging free radicals and the brain’s protective antioxidants—may be at the heart of depression’s complex biology (PsyPost).

This discovery is particularly meaningful in Thailand, where depression is becoming more widely recognized and discussed, yet biological risk factors remain less understood among the public. Mental health issues, including depression, are prevalent in the country, affecting individuals across various backgrounds, and contribute to personal suffering, economic loss, and significant stigma. Understanding the underlying biology of depression is thus not just academically interesting, but also a potential key to more effective prevention and treatment in Thai society.

A large meta-analysis in the field of neuroscience finds that individuals with major depressive disorder have significantly lower levels of the brain’s primary antioxidant, glutathione, in the occipital cortex. The study adds to growing evidence that oxidative stress plays a role in depression’s complex biology. In Thailand, where public understanding of mental health is expanding, these insights may help reduce stigma and improve prevention and treatment strategies.

The analysis pooled data from eight studies that used proton magnetic resonance spectroscopy to measure glutathione in living participants. The sample included 230 individuals diagnosed with major depressive disorder and 216 healthy controls. Researchers focused on two brain regions: the occipital cortex, important for visual processing, and the medial frontal cortex, linked to emotion and decision-making.

A landmark study from the University of Edinburgh shows that children who struggle to regulate their emotions by age seven face a higher risk of anxiety and depression in adolescence. An analysis of nearly 19,000 participants found that early emotional dysregulation predicts later internalizing problems, such as sadness, worry, and fear. The research underscores the importance of teaching emotional coping skills in childhood, with clear implications for parents and educators in Thailand and beyond.

A new study led by the University of Edinburgh has found that children who struggle to manage their emotions as early as age seven are at a much higher risk of developing anxiety and depression during their teenage years. The research, published in the Journal of Affective Disorders and funded by the UK’s Medical Research Foundation, tracked nearly 19,000 young people and uncovered a clear connection between early difficulties with emotion regulation and later internalizing problems such as sadness, worry, and fear. The findings highlight the critical importance of teaching emotional coping skills in childhood—a lesson with profound implications for parents and educators in Thailand and around the world Neuroscience News.

A groundbreaking small study reported this week suggests that a single dose of psilocybin—the active compound in so-called “magic mushrooms”—may provide significant antidepressant effects that last at least five years for most patients. This finding, detailed in Live Science, could herald a new era in mental health treatment strategies, especially for those battling persistent depression.

The importance of this research resonates across the globe and holds particular interest for Thailand, where mental health care has experienced increased public attention and evolving social attitudes in recent years. Historically, treatment protocols for depression in Thailand have primarily relied on psychotherapy and long-term pharmacological interventions, yet many patients continue to suffer relapse or side effects. Emerging research on psychedelic-assisted therapy, such as this recent study, offers hope for more durable solutions and challenges existing stigmas surrounding mental health and controlled substances.

A single guided dose of psilocybin, the psychoactive compound in magic mushrooms, may provide long-lasting relief from depression lasting years for some patients. While the study is small, researchers report improvements in mood and depressive symptoms for up to five years after treatment under clinical supervision. The research adds to growing global interest in psychedelic-assisted therapy as a potential long-term option for major depressive disorder, a condition affecting millions worldwide, including many in Thailand.

A recent, small study indicates that a single dose of psilocybin—the active compound in magic mushrooms—could provide significant antidepressant effects for years. The findings, published and discussed in science coverage, point to potential breakthroughs in how depression is treated, particularly for patients who struggle with relapse.

The research resonates globally and holds particular relevance for Thailand, where mental health care has gained public attention in recent years. Traditional Thai treatment for depression has relied on psychotherapy and long-term medications, but many patients still experience relapse or adverse effects. Emerging evidence on psychedelic-assisted therapy offers hope for more durable solutions and invites thoughtful discussion about how society views controlled substances and mental health care.