#Dioscoreahispida

In the vast herbal apothecary of Thai tradition, few remedies inspire as much fascination—and caution—as “กลอย” (Kloi), known in science as Dioscorea hispida Dennst. Revered by generations for its potent medicinal properties, yet infamous for its toxic nature, Kloi epitomizes the delicate balance between healing and harm inherent in many of nature’s gifts. This enigmatic tuber, found lurking beneath the forest floor across Southeast Asia, has sustained communities during times of hardship, but also demands deep cultural respect and wisdom in its preparation. Today, modern science is peeling back the layers of mystery surrounding Kloi, revealing how ancient detoxification rituals have a foundation in chemistry and pharmacology, while new applications in medicine and cosmetics beckon—but not without important warnings.

Kloi, known scientifically as Dioscorea hispida Dennst, stands out in Thai herbal lore for its dual identity: powerful medicine and dangerous toxin. Among communities across Southeast Asia, this tuber has sustained people through scarcity while demanding careful preparation and deep cultural respect. Modern science is now clarifying the chemistry behind traditional detox rituals and exploring safe, practical uses in health and cosmetics, all with crucial cautions.

In Thailand, Kloi has long appeared in both cuisine and folk medicine, especially in the Northeast and North. Local names vary by region, including man kloi, kloi khao nei, and kloi nok. Raw Kloi contains potent toxins such as dioscorine, an alkaloid that can paralyze the nervous system, and cyanogenic compounds that can release cyanide if improperly processed. These dangers did not stop communities from relying on Kloi during famine or as a traditional remedy, but they underscored the need for careful detoxification practices handed down through generations.