#Diphenhydramine

A widely used allergy medication, diphenhydramine—best known by the brand name Benadryl—is facing new scrutiny from health experts, who now argue that its risks outweigh its usefulness, particularly when safer alternatives are available. In a recent review published by leading allergy specialists from Johns Hopkins University and the University of California, San Diego, calls have intensified for this first-generation antihistamine to be pulled from over-the-counter (OTC) and prescription markets in the United States, igniting worldwide interest and concern, including in Thailand where similar medications are popular.

A common allergy medicine widely sold across Thai pharmacies faces growing international safety concerns. Diphenhydramine, best known as Benadryl, is being scrutinized by leading medical experts who warn its risks may outweigh benefits for many users.

Research from top institutions highlights safer alternatives that are particularly suitable for Thai families seeking allergy relief. Data from international studies suggest a shift toward second-generation antihistamines with improved safety profiles.

Diphenhydramine has occupied Thai medicine cabinets since the mid-20th century. In addition to treating seasonal allergies, it is used for insect bites, sleep difficulties, and some cold symptoms. The drug is readily available across Thailand’s network of pharmacies, with many products accessible without prescriptions.

Millions of people across the globe rely on Benadryl, a common over-the-counter allergy medication, for relief from runny noses and itchy skin. However, a fresh wave of scientific evidence is raising serious concern about the long-term safety of its key ingredient, diphenhydramine. A recent study and mounting medical warnings have drawn direct links between regular Benadryl use and a higher risk of developing crippling diseases such as dementia and Alzheimer’s, prompting doctors to urge consumers, including those in Thailand, to reconsider their treatment choices.

Recent research prompts clinicians to rethink the safety of Benadryl, whose active ingredient diphenhydramine is a sedating anticholinergic. Studies indicate that frequent, long-term use may be associated with a higher risk of dementia and Alzheimer’s disease, particularly among older adults. Thai doctors advocate discussing safer alternatives with healthcare providers.

The findings carry special weight in Thailand, where self-medication with antihistamines is common and the population is aging. Dementia already affects many families in Thailand, adding pressure to the healthcare system. Data from national health authorities and global health bodies underscores the importance of addressing modifiable risk factors to protect cognitive health later in life.