#Endocrinology

A new international study has revealed that even modest increases in blood sugar levels—not just advanced diabetes—can have a significant negative impact on men’s sexual health as they age, shifting the traditional understanding of male reproductive well-being. The latest findings, presented at the Endocrine Society’s ENDO 2025 annual meeting in San Francisco, spotlight metabolic health, especially mild hyperglycemia, as a key driver in changes to sexual functioning among men, offering a new roadmap for prevention and intervention.

A growing body of new research is shedding light on a potential link between vitamin D supplementation and a reduced risk of developing type 2 diabetes among individuals with high-risk prediabetes. Recent studies suggest that boosting vitamin D levels in those who are already at risk could slow or even prevent the onset of overt diabetes—a finding that may have significant implications for the millions of people in Thailand and worldwide who are living with prediabetes.

Recent global headlines have sparked intense debate and curiosity as leading experts speculate whether the rise in average penis size observed in recent years might be connected to the explosion of weight-loss medications such as Ozempic and Wegovy. A convergence of anecdotal reports and emerging data has prompted scientific and medical communities—and the general public—to seek explanations for this unexpected trend, which could have far-reaching implications for men’s health and societal perceptions in Thailand and worldwide.

A new study published this week has dramatically shifted the landscape of diabetes research, revealing that hyperactivity within a specific set of neurons in the brain—AgRP neurons in the hypothalamus—may drive type 2 diabetes, regardless of weight or obesity. Scientists from the University of Washington demonstrated that by silencing these neurons in mice, blood sugar levels normalized for months, even as the animals’ weight and food intake remained unchanged—a finding that upends decades of established beliefs about diabetes origins and opens compelling new treatment avenues (Neuroscience News).

A growing body of research and expert opinion is highlighting a silent yet serious consequence of excessive abdominal fat in men: a dramatic impact on hormonal balance, sexual health, and fertility. As obesity rates continue to rise—across the world and notably in Asian countries including Thailand—doctors are warning that belly fat is much more than a cosmetic concern. Landmark findings discussed by leading endocrinologists reveal that fat surrounding the waistline acts as an endocrine organ, disrupting testosterone levels and overall male vitality (The News).

Popular health trends recently have seen a surge in interest in so-called “cortisol bellies” and “cortisol faces,” fueled by viral social media posts and a spike in online searches for cortisol-related health advice. These buzzwords, while catchy, attempt to simplify the highly complex biological processes behind how our bodies respond to chronic stress—sometimes sparking unnecessary worry among Thai and global audiences.

Cortisol, often dubbed the “stress hormone,” is produced by the adrenal glands and plays a critical role in helping the body respond to stress. When stress levels rise, so does the production of cortisol, which can affect multiple body systems—regulating metabolism, controlling blood sugar, influencing immune responses, and aiding in fat storage. According to a recent report by the National Post, online searches for information on cortisol, its “trigger foods,” and supposed “cortisol detoxes” have climbed dramatically in the past year, reflecting the growing anxiety about how stress hormones may visibly influence appearance and health (MSN).

Scrolling through TikTok or social media, many Thai readers may have encountered alarming claims asserting that stress-induced cortisol is the main culprit behind stubborn belly fat and unwanted facial changes, often labelled “cortisol belly” and “cortisol face”. However, a recent analysis published by The Conversation dispels much of this online panic, highlighting that the scientific evidence paints a far more nuanced picture and suggesting Thais need not obsess over this hormonal hype.

Social media’s obsession with “cortisol belly” and “cortisol face” has racked up millions of views among Thai users, amplifying fears that the stress hormone cortisol is sabotaging health and appearance. However, scientists and medical experts are pushing back, clarifying that everyday cortisol fluctuations from modern stressors are far from the catastrophic threat depicted in TikTok and Instagram trends—findings that come as a relief for many in Thailand and across the globe. This latest conversation is rooted in a detailed analysis published by a medical researcher through The Conversation, and corroborated by endocrinologists and global health organizations, signaling an urgent need for critical media literacy around health information online.