Scientists Uncover Sleep’s True Trigger: Mitochondria May Hold the Key
A groundbreaking study by researchers at the University of Oxford has illuminated one of biology’s oldest mysteries: why we need sleep. According to the latest research published in Nature, the answer may lie not in the brain’s intricate circuitry but deep within the mitochondria—the cell’s microscopic power plants. The findings could ultimately reshape our understanding of sleep, fatigue, and related health conditions, both for Thais and people worldwide.
For generations, scientists have puzzled over how the body measures sleep need. The prevailing wisdom held that specific brain networks monitored wakefulness, but the new study demonstrates that small changes within the mitochondria of neurons may directly signal when it’s time to rest. This revelation, based on experiments using fruit flies (Drosophila melanogaster), overturns decades of assumptions and offers hope for new treatments of sleep disorders—a global and Thai public health concern.