Exercise-Linked Brain Gene Signal Sparks Hope for Alzheimer’s Prevention in Thailand
A new study from Harvard Medical School and Massachusetts General Hospital highlights ATPPIF1, a brain gene activated by exercise that may slow cognitive decline in Alzheimer’s patients who cannot exercise. Published in Nature Neuroscience, the findings suggest potential drugs or gene therapies that mimic exercise’s brain benefits. The discovery is particularly relevant for Thailand’s aging population.
For years, researchers have shown that physical activity can slow cognitive decline in Alzheimer’s and related dementias. But many patients, especially those with frailty or advanced disease, cannot exercise. The study addresses this gap by uncovering molecular pathways that exercise influences, pointing to interventions that stimulate these pathways directly in the brain.
