#Formate

A groundbreaking new study has unveiled how transformative interactions between exercise, gut microbes, and the immune system may significantly improve the effectiveness of cancer immunotherapy—a revelation that could inspire new treatment strategies for Thai cancer patients and shape global oncology protocols. Researchers at the University of Pittsburgh, publishing in the journal Cell, demonstrated for the first time in mice that exercise reshapes the gut microbiome, leading to the production of a powerful compound called formate, which boosts the body’s cancer-fighting immune response and enhances outcomes from immunotherapy (medicalxpress.com).

A new study links exercise, gut microbes, and the immune system, offering a potential way to improve cancer immunotherapy for Thai patients. Researchers at a leading U.S. university found that regular exercise reshapes the gut microbiome and increases a metabolite called formate. Formate enhances CD8 T cells, strengthening the body’s attack on cancer and improving responses to immune checkpoint inhibitors. The findings point to a practical, accessible approach to boost treatment outcomes in Thailand and inform global oncology practices.