Protein FTL1 Reversed Memory Loss in Mice — What Thailand Should Know
Researchers say a protein called ferritin light chain 1 (FTL1) can be dialled down to restore memory performance in aged mice, a finding described as a true reversal of age-related cognitive decline rather than simple slowing. The study used genetic tools and viral delivery to reduce FTL1 in the hippocampus, the brain’s memory centre, and reported that older mice regained memory and learning abilities comparable to much younger animals. Published in a leading ageing journal, the experiment points to iron-handling and cellular energy as central mechanisms in normal brain ageing and opens a new therapeutic avenue distinct from decades of Alzheimer’s research focused on amyloid and tau. For Thai readers worried about a parent’s forgetfulness or the growing social and economic cost of cognitive decline, the study brings hope but also important caveats about how mouse findings translate to humans.