#Genetherapy

In a promising turn for Alzheimer’s disease research, scientists at Harvard Medical School and Massachusetts General Hospital have identified a gene activated during physical exercise that could be targeted to slow cognitive decline in patients unable to exercise. This discovery, detailed in a recent study published in Nature Neuroscience, could pave the way for drug therapies that replicate the brain-boosting effects of exercise—offering renewed hope for millions, including Thailand’s rapidly aging population, at risk of dementia and related conditions.

A new study from Harvard Medical School and Massachusetts General Hospital highlights ATPPIF1, a brain gene activated by exercise that may slow cognitive decline in Alzheimer’s patients who cannot exercise. Published in Nature Neuroscience, the findings suggest potential drugs or gene therapies that mimic exercise’s brain benefits. The discovery is particularly relevant for Thailand’s aging population.

For years, researchers have shown that physical activity can slow cognitive decline in Alzheimer’s and related dementias. But many patients, especially those with frailty or advanced disease, cannot exercise. The study addresses this gap by uncovering molecular pathways that exercise influences, pointing to interventions that stimulate these pathways directly in the brain.

A groundbreaking Japanese study has revealed that vitamin C can help reverse age-related thinning of the skin by activating so-called “youth genes,” offering hope to many Thais concerned about healthy aging and skin rejuvenation. This research, published in the Journal of Investigative Dermatology on April 20, 2025, demonstrates for the first time that vitamin C works at the genetic level to promote thicker, healthier skin in ways that extend beyond its antioxidant reputation and traditional beauty claims (sciencedaily.com).