#Genetics

A groundbreaking genetic study has revealed that autism spectrum disorder (ASD) is made up of at least four scientifically distinct subtypes, each with its own unique symptom pattern, developmental trajectory, and genetic profile, according to research published in Nature Genetics and highlighted by Psychology Today (). This new framework changes how autism is understood and may pave the way for more personalized support and interventions—an important message for Thai parents, educators, and health professionals seeking clarity amidst the complexity of ASD.

A groundbreaking new study is raising the possibility that humans harbor genetic “superpowers” linked to hibernation, offering hope for advancing treatments against obesity, diabetes, and neurological damage. Researchers believe that genes regulating hibernation—long thought unique to animals like bears and ground squirrels—are present and functional in the human genome, potentially unlocking revolutionary tools for medicine and health maintenance (livescience.com).

This revelation stems from a pair of studies published in the prestigious journal Science, where geneticists at the University of Utah showed that genes regulating core features of hibernation exist in both hibernating mammals and people. If harnessed, this dormant genetic code could help control metabolism, defend the brain against damage, and spark new advances in treating metabolic disorders. For Thai readers, this research signals potential new strategies in national health campaigns battling non-communicable diseases like type 2 diabetes and obesity, two of Thailand’s most urgent public health issues.

Deep within every Thai citizen’s DNA lies a remarkable genetic legacy from humanity’s distant past—hibernation genes that once allowed our ancestors to survive harsh environmental conditions through dramatic metabolic adjustments. Revolutionary research published in the journal Science reveals these dormant genetic programs may hold the key to combating Thailand’s escalating diabetes and obesity epidemics while offering unprecedented insights into human metabolic resilience.

Scientists at the University of Utah have identified conserved genetic elements that regulate hibernation-like metabolic states across mammalian species, including humans. These “hibernation hub genes” control processes that allow animals to bulk up rapidly, enter profound metabolic dormancy, resist neurological damage during blood flow disruptions, and emerge healthy after months of minimal activity. Most remarkably, these same genetic pathways exist within human genomes, potentially accessible through targeted therapeutic interventions.

Groundbreaking international research unveils the strongest scientific evidence yet that human genes and biological sex fundamentally determine how individuals experience and interpret smells, opening revolutionary possibilities for personalized medicine and deeper understanding of neurological health. The landmark study, conducted by University of Leipzig researchers and published in Nature Communications, identified ten distinct genomic regions directly connected to specific odor detection abilities, with seven representing entirely new scientific discoveries. Most remarkably, three of these genetic regions demonstrate sex-specific activation patterns influenced by hormone fluctuations, explaining why scent perception can shift dramatically during menstruation, pregnancy, and other life transitions.

A landmark international study has uncovered the strongest evidence yet that our genes—along with biological sex—shape how we experience smells, opening new possibilities for understanding brain health and personalized medicine. The research, conducted by the University of Leipzig and published on July 30, 2025, in Nature Communications, identified ten distinct regions of the human genome connected to the ability to detect specific odors. Remarkably, seven of these genetic links had never before been documented, while three regions proved sensitive to sex-specific factors such as hormones, helping explain why smell perception can shift during life events like menstruation or pregnancy.

Revolutionary scientific discoveries published in the prestigious journal Science reveal that humans possess dormant genetic “superpowers” inherited from hibernating mammals that could fundamentally transform treatment approaches for chronic diseases including type 2 diabetes and Alzheimer’s disease—conditions that disproportionately affect Thailand’s aging population and strain the nation’s healthcare infrastructure. This groundbreaking research from University of Utah scientists identifies specific DNA regulatory regions that enable hibernating animals to recover completely from months of physical decline, with these same genetic elements present and potentially activatable in human genomes, opening unprecedented pathways for therapeutic interventions.

The concept of humans carrying dormant genetic “superpowers” for healing may seem like science fiction, but emerging research suggests it’s closer to reality than once believed. In a pair of groundbreaking studies published July 31, 2025, in the journal Science, researchers at the University of Utah have identified specific DNA regions in hibernating mammals that underlie their remarkable resilience—allowing them to recover from months of physical decline without lasting harm. Even more promising, these same genetic elements may be present and potentially activatable in the human genome, opening new pathways for treatments of chronic diseases such as type 2 diabetes and Alzheimer’s disease (Gizmodo; MedicalXpress).

A decade-long study has brought comforting news for older adults wary of Alzheimer’s disease: taking regular walks could significantly reduce the risk of cognitive decline, especially for those with a genetic predisposition to the condition. Presented at the 2025 Alzheimer’s Association International Conference, this large-scale study tracked nearly 3,000 participants aged 70 to 79 over ten years, finding that those who maintained or increased their daily walking habits experienced notable improvements in processing speed and executive function compared to those who remained sedentary or reduced activity levels (CNN).

A new wave of technological advances promises parents a chance to have “high-quality” families by screening embryos for optimal genetic health, but current research and social debate show that the quest for genetic perfection may come at significant ethical, cultural, and emotional costs. As genetic screening companies like Orchid promote the ability to select embryos free from a wide array of health risks, a chorus of bioethicists, parents, and social critics warn that this trend risks making children into consumer products and overlooks the unpredictability—and inherent value—of imperfect human lives (The Dispatch).

In a landmark study challenging widespread beliefs about heredity and mental health, researchers have found that the majority of cases of serious mental illnesses such as schizophrenia, bipolar disorder, and depression arise in individuals with no close family history of these conditions. The research, covering data from over 3 million people, calls for a shift in how mental health is understood and addressed both globally and within Thailand’s evolving mental health landscape (Neuroscience News).

For many Thais, cilantro (known locally as phak chee) is inseparable from everyday cuisine — sprinkled on tom yum, incorporated into larb, or simply used as a fresh garnish on soups and street-side noodles. Yet, a curious minority recoil at its presence, describing its taste as reminiscent of soap. Recent research confirms this odd aversion is grounded in genetics rather than culinary preference, reshaping our understanding of food appreciation in Thailand and globally.

A groundbreaking new study published in Science Advances has upended the commonly held belief that the sex of a baby is purely a matter of chance, revealing that birth sex patterns within families may follow unique, weighted probabilities. This research—based on more than 146,000 pregnancies from over 58,000 women across nearly six decades—suggests that some families have a higher likelihood of producing multiple children of the same sex, offering fresh insight into age-old questions about why some parents end up with, for instance, “all girls” or “all boys” (Washington Post).

A wave of new scientific discoveries is poised to transform how autism is diagnosed, with the latest research pointing to a likely surge in cases—especially among groups historically overlooked by current diagnostic methods. Researchers from Princeton University and the Simons Foundation have identified four genetically distinct autism subtypes, a landmark achievement that could finally explain why some children go undiagnosed for years and why girls and children with subtler symptoms are more likely to be missed. This genetic blueprint promises not only earlier and more accurate identification, but also the possibility of personalized interventions and the reduction of stigma for affected individuals and families. The findings, published in a recent issue of Nature Genetics, signal a seismic shift in understanding and managing autism, with major implications for diagnostics and treatment worldwide—including in Thailand, where autism remains widely misunderstood and underdiagnosed.

Prostate cancer, the second most commonly diagnosed cancer among men worldwide, is again in the headlines as global cases continue to rise and new research underscores the urgent need for preventive measures. Recent estimates from the National Cancer Institute forecast more than 300,000 new cases in 2025 alone, marking prostate cancer as an escalating public health challenge not only globally but for Thailand’s aging male population. As medical experts intensify calls for awareness and regular screenings, cutting-edge studies are shining a light on modifiable lifestyle factors that may help stem the tide of this disease.

A groundbreaking study from Harvard researchers has highlighted a novel approach to fighting cognitive decline associated with Alzheimer’s disease—one that does not require physical exertion but instead targets specific genes in the brain to replicate the beneficial effects of exercise. This research opens new avenues for treatments, particularly for those unable to engage in regular physical activity due to frailty or advanced symptoms.

Cognitive decline and Alzheimer’s disease remain pressing public health challenges globally, including in Thailand where a rapidly aging society faces rising rates of dementia. Traditionally, regular physical activity such as aerobic exercise has been strongly linked to slower cognitive deterioration and improved brain health. However, as experts note, many elderly patients—especially in the later stages of cognitive disorders—find it increasingly difficult to maintain an active lifestyle. This reality has driven scientists to explore the genetic and molecular pathways triggered by exercise, aiming to offer the same neuroprotective benefits via medical interventions.

A groundbreaking new study has found that individuals with higher IQs possess a significantly greater ability to predict life events, resulting in better-informed decision-making. The research, led by the University of Bath’s School of Management and published in the Journal of Personality and Social Psychology, sheds light on the crucial role intelligence plays not only in academic and occupational achievements but also in everyday judgments about health, finances, and personal safety. For Thai readers, understanding these findings could prove essential in navigating critical choices for both personal and national development.

In a landmark scientific breakthrough, researchers have engineered fruit flies to voluntarily consume cocaine, establishing the world’s first insect model for studying the genetic and neurological roots of cocaine addiction. This innovative approach, announced in the Journal of Neuroscience and led by experts at the University of Utah, promises to accelerate the discovery of effective treatments for one of the most challenging substance use disorders worldwide, opening new horizons for both basic research and therapeutic development (NeuroscienceNews.com).

Drinking a daily cup of coffee may do more than provide a morning pick-me-up—it could help women stay mentally sharp and physically robust as they age, according to a landmark 30-year study that followed nearly 50,000 women in their midlife years. The research, which stands out for its unprecedented scale and scope, found that women who consumed regular, caffeinated coffee were significantly more likely to age without developing serious diseases, cognitive decline, depression, or physical frailty. This discovery offers fresh hope to coffee lovers in Thailand and beyond, while also urging a more nuanced look at the relationship between genetics and nutrition as Thais seek to promote healthy aging in an era of rapid demographic change.

In a scientific advance with potential global impact, researchers have engineered the world’s first fruit fly model of cocaine addiction—an innovation that promises to accelerate our understanding of cocaine use disorder and speed the development of effective treatments. By genetically modifying fruit flies to disable their bitter-sensing receptors, a research team led by a psychiatry specialist at the University of Utah has successfully encouraged addictive, voluntary cocaine self-administration in the insects, an outcome described in their recent Journal of Neuroscience publication and highlighted by Neuroscience News.

Prostate cancer has once again captured global attention following the recent diagnosis of former US President Joe Biden, shining a spotlight on a disease that is the most common cancer among men worldwide. While headlines often tout new prevention measures or promising lifestyle tweaks, leading experts have clarified that the factors most responsible for a man’s risk of developing prostate cancer lie largely beyond individual control: age, ethnicity, and family history. This evidence-based perspective, backed by the latest research, has vital implications for men in Thailand, where rising cancer rates are signaling the need for smarter screening and public health strategies.

The assumption that mental disorders are largely inherited from our parents—a bedrock belief of biological psychiatry for decades—is now under serious scrutiny. According to a detailed new analysis published in May 2025, current research demonstrates that heritability explains far less about mental illness than previously assumed, prompting renewed calls for a broader understanding of the interplay between genes, environment, and psychology in shaping mental health (Madin America).

Why does this matter for Thai readers? In a country where mental health awareness is only now gaining national attention, public discourse often echoes global trends in medicine and psychiatry, including an emphasis on genetic causation. Many Thais, especially in urban areas, may be told that conditions like depression, anxiety, or schizophrenia run in families and are predominantly genetic. Understanding that mental disorders stem from more than just DNA could help counter stigma, inform policy, and inspire more comprehensive mental health support across the country.

A new discovery is sending ripples through the medical world: scientists have identified a gene called PHGDH not just as a bystander but as a direct cause of Alzheimer’s disease, potentially changing the diagnosis and treatment of this devastating condition. Uncovering a previously unknown function of this gene, researchers have also pinpointed a candidate drug-like compound that may one day prevent or slow the disease in its earliest stages – a major leap forward, especially for aging societies like Thailand.

A century-old mystery surrounding the striking orange coats of domestic cats has finally been unraveled by new genetic research published on May 15 in the journal Current Biology (source). Scientists have identified a unique “meow-tation” in feline DNA that not only gives orange cats their distinctive hues, but also explains why the vast majority of them are male—a question that has perplexed geneticists and cat fanciers alike since the early 20th century.

A recent international study has revealed that higher concentrations of caffeine in the blood may help reduce body fat and lower the risk of developing type 2 diabetes, sparking fresh debate about caffeine’s broader health effects for Thais and coffee lovers worldwide. The findings, published in BMJ Medicine and involving researchers from the Karolinska Institute in Sweden, University of Bristol, and Imperial College London, point to new possibilities for managing obesity and diabetes—two major public health challenges in Thailand—by leveraging something as simple as a cup of coffee.