Refined brain map highlights aging hotspots and implications for Thailand’s health future
A new single-cell brain map in Nature reveals which cell types and regions are most affected by aging, offering guidance for Thailand’s aging population. Researchers at the Allen Institute for Brain Science analyzed over 1.2 million brain cells from young and older mice, spotlighting a vulnerability hotspot in the hypothalamus. The hypothalamus regulates hunger, hormones, and energy balance, suggesting links between aging, metabolism, and cognitive changes.
Data from leading neuroscience centers show aging affects the brain unevenly. Rather than a uniform decline, specific cell types undergo distinct gene-expression changes over time. Using single-cell transcriptomics, investigators compared gene activity across life stages akin to human young adulthood and middle age. The study identified 2,449 genes with age-related changes, concentrated mainly in the hypothalamus, pointing to a potential target for interventions aimed at healthy aging and neurodegenerative disease prevention.