#Ketones

A new study in the Journal of Physiology reveals a strong liver–brain connection: ketones produced by the liver during exercise may support cognitive health, offering hope for those with liver challenges. Researchers from a leading U.S. university showed that when liver cells lose the ability to make ketones, brain energy and learning decline. Remarkably, endurance exercise could reverse these brain changes, hinting at a backup system that helps protect aging minds.

A groundbreaking new study published in the Journal of Physiology has unveiled a striking connection between the liver’s metabolic function and brain health, highlighting the crucial role of liver-produced ketones during exercise—and raising intriguing possibilities for combating cognitive decline, even among those with liver impairments. Conducted by researchers at the University of Missouri, the research demonstrates that when liver cells lose the ability to make ketones, cognitive and mitochondrial function in the brain suffer. Remarkably, endurance exercise was found to reverse these negative effects, suggesting a possible “backup system” that could protect the aging brain and offer new hope to individuals with liver disease (psypost.org).

A groundbreaking study published in the Journal of Physiology has revealed a remarkable connection between the liver and the brain, suggesting that ketones produced by the liver—especially during exercise—play a key role in keeping the brain healthy and maintaining memory function. The latest research, conducted by a team from the University of Missouri, shows that when the liver’s ability to produce ketones is blocked, rats experience memory deficits and diminished brain mitochondrial function, but that regular endurance training can effectively reverse these cognitive problems, even when ketone production is hampered (psypost.org).

A new study in the Journal of Physiology reveals a strong connection between the liver and the brain. Liver-produced ketones, especially during exercise, appear to support brain health and memory. In rats, hindering the liver’s ketone production led to memory deficits and reduced brain mitochondrial function, while sustained endurance training reversed these effects even when ketone production was impaired. These findings come from researchers at a major U.S. university and were summarized by PsyPost.

New research from the University of Missouri shows that exercise still provides clear cognitive benefits even when the brain’s energy supply is down. The study, published in The Journal of Physiology, reveals that physical activity protects and improves thinking skills even if ketone production in the liver is limited. For aging populations in Thailand facing memory concerns and daily stress, this finding adds a practical motivation to move more consistently.

Even when the brain is running low on its regular energy supply, a new study from the University of Missouri reveals that exercise continues to deliver significant benefits—underscoring just how powerful physical activity can be for mental sharpness and cognitive health (https://showme.missouri.edu/2025/exercise-boosts-brain-health-even-when-energy-is-low/). For Thai readers concerned about aging, memory loss, or the daily stresses that sap our mental energy, these findings provide a timely nudge to make movement a routine part of life. The research, recently published in The Journal of Physiology, demonstrates that even when the liver is unable to generate ketones, an essential alternative brain fuel, exercise can still protect and restore cognitive function.