#Marathon

An 85-year-old runner challenging his limits at the 28th London Marathon is capturing international attention and spotlighting new research that shatters one of the most persistent myths in health: that old age is an obstacle to exercise. While some see retirement as an end to physical activity, the remarkable story of this octogenarian marathoner signals a broader move in both science and society towards active aging — and offers invaluable lessons for Thailand’s fast-growing elderly population.

A recent study by researchers at the University of the Basque Country, published in Nature Metabolism, found that marathon running can temporarily reduce myelin content in the brain. Importantly, these changes are fully reversible within two months, offering reassurance to endurance athletes concerned about lasting neural effects.

As Bangkok’s marathon scene grows, this finding is particularly relevant for Thai runners who tackle the 42-kilometer challenge. The study introduces the concept of metabolic myelin plasticity, suggesting that during intense exercise the brain may tap myelin lipids as an additional energy source when glucose is scarce. This aligns with established knowledge that glycogen stores deplete during long efforts, prompting the body to adapt its energy pathways.

A small, cutting-edge study suggests the brain may temporarily convert its own myelin into fuel during extreme endurance events like marathons. This unexpected mechanism could help protect overall brain function when glucose supply drops during intense exercise.

Researchers in Spain followed 10 marathon runners, scanning their brains with MRI before and after the races. They found that 24 to 48 hours after finishing a grueling 42-kilometer run, myelin levels in key brain regions—those governing movement, coordination, sensation, and emotion—decreased noticeably. Importantly, these changes were not permanent. By two weeks post-race, myelin began to recover, and most participants returned to baseline within about two months.

A small pilot study suggests the brain may tap its own energy reserves during intense endurance efforts. Spanish researchers observed changes in brain white matter among marathon runners, hinting at a form of neuroplasticity that could help preserve function under extreme physical stress.

Researchers conducted MRI scans on ten endurance runners (eight men and two women) before and after a 42-kilometer race. The scans showed a measurable drop in myelin, the fat-rich sheath around nerve fibers that facilitates rapid signaling. The decrease was most evident in brain regions responsible for movement, balance, sensory processing, and emotion. Notably, myelin levels began to recover within 24 to 48 hours after the race and largely returned to baseline within two months for the six participants who had follow-up scans.