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A groundbreaking study by researchers at Japan’s Fujita Health University has uncovered an unexpected role for brain-derived estrogen in directly regulating appetite and body weight, upending traditional beliefs about how hormones shape our eating habits. Their findings, recently published in The FEBS Journal, not only broaden our scientific understanding but could also open new avenues for treating obesity and overeating—issues of increasing significance in Thailand and around the world (PsyPost).

A new study from researchers at Fujita Health University in Japan reveals that estrogen produced in the brain may directly regulate appetite and body weight, challenging long-held beliefs about hormonal control of eating. Published in The FEBS Journal, the findings offer fresh directions for obesity research and potential future therapies relevant to Thai health priorities.

Traditionally, estrogen has been associated with reproductive health. Yet recent work shows the brain itself can synthesize estrogen, especially in the hypothalamus, via the enzyme aromatase. This neuroestrogen may influence behavior and physiological processes beyond reproduction. Until now, its direct impact on appetite remained uncertain, prompting interest from endocrinologists and neuroscientists worldwide.