#Mdma

A groundbreaking study published in Molecular Psychiatry reveals that LSD, unlike MDMA and d-amphetamine, alters brain connectivity in distinctive ways, reshaping our understanding of how these substances affect the human brain. Conducted by researchers at the University of Lübeck, this study is pivotal for psychiatry, underscoring the nuanced differences between substances often grouped under the “psychedelics” label.

The research utilized functional magnetic resonance imaging (fMRI) to observe brain activity in 25 healthy volunteers under the influence of LSD, MDMA, and d-amphetamine. The study found that while all three psychotropics disrupted communication within brain networks, LSD uniquely affected regions associated with self-awareness and sensory processing. These insights highlight the inaccuracy of lumping LSD with other psychedelics like MDMA, often wrongly presumed to have similar effects due to their shared primary action on serotonin 2A receptors.

A European university-led study used fMRI to show that LSD alters brain connectivity in distinct ways from MDMA and d-amphetamine. The findings challenge the broad “psychedelics” label and highlight the need to analyze each drug’s specific brain effects for promising therapeutic insights.

The research scanned 25 healthy volunteers under the influence of LSD, MDMA, and d-amphetamine. All three substances disrupted communication within brain networks, but LSD uniquely impacted regions tied to self-awareness and sensory processing. This helps explain why LSD often produces profound perceptual changes and shifts in the sense of self, while MDMA and d-amphetamine yield different subjective experiences.