#MedicalResearch

A new study in Aging suggests senolytics—drugs once linked to anti-aging benefits—may slow Alzheimer’s disease progression. The findings are hopeful for millions affected by the condition, and they come as Thailand’s aging population grows. Experts urge cautious interpretation and careful clinical use as research continues.

Alzheimer’s disease involves amyloid-beta plaques in the brain, a factor associated with cognitive decline. The Thai audience especially understands the burden as families increasingly care for elderly relatives. The international study investigated six compounds known for anti-aging or cognitive-enhancing effects, including dasatinib and nintedanib, both considered senolytics. When tested on brain tissue from individuals with Alzheimer’s, these compounds appeared to selectively reduce pathological forms of brain enzymes linked to the plaques—without harming normal enzyme function.

In a groundbreaking new study published in the journal Aging, researchers have discovered that senolytics—compounds traditionally known for their anti-aging properties—might be able to slow the progression of Alzheimer’s disease. This finding offers a glimmer of hope to the millions impacted by Alzheimer’s, particularly as Thailand sees a growth in its aging population. The study’s promising results have sparked a renewed interest in senolytics, albeit with caution from the medical community about their application.

A recent study from Johns Hopkins Medicine unveils a new mechanism by which brain cells communicate, using advanced cryo-electron microscopy to show how the neurotransmitter glutamate activates AMPA receptors. This research could lead to therapies for epilepsy and certain intellectual disabilities, offering fresh hope for patients in Thailand and beyond.

The work clarifies the interplay between ion channels and neurotransmitters that underpins brain signaling. Glutamate is a key messenger that modulates AMPA receptors, which control ion flow into neurons and, in turn, electrical communication across neural networks. By capturing freeze-frame images of these channels in action, researchers gained rare insight into how the receptors open and close and where drugs might intervene.

In a groundbreaking study that could revolutionize treatments for neurological disorders, researchers at Johns Hopkins Medicine have identified a novel mechanism of brain cell communication through advanced cryo-electron microscopy (cryo-EM), revealing how the neurotransmitter glutamate activates brain receptors. This could pave the way for new therapeutic options to address conditions like epilepsy and certain intellectual disabilities.

The research sheds light on the intricate dance of ion channels and neurotransmitters that enable our brains to function. Glutamate, a critical signaling molecule, influences AMPA receptors—channels that control the flow of ions into neurons, thereby facilitating electrical communication within the brain. The team’s innovation lies in capturing freeze-frame images of these channels in action, providing unprecedented clarity on their operation and potential drug interaction points.

A recent study in a leading medical journal highlights a surge in invasive Group A Streptococcus infections in ten U.S. states. The report covers about 35 million people over ten years and shows cases doubling since 2022. For Thai audiences, this underscores the importance of understanding alert signs and preventive care in a globally connected world.

The condition is linked to necrotizing fasciitis, a serious infection that destroys soft tissue, and sepsis, a life-threatening response to infection. Although the rise is outside Thailand, the findings emphasize vigilance at home, especially as international travel and trade rise. Public health experts stress the need for timely medical attention when symptoms appear.

A recent study published in the Journal of the American Medical Association has raised alarms over the increasing prevalence of invasive Group A Streptococcus (GAS) infections, more infamously known as the flesh-eating disease, across ten states in the United States. This extensive research, covering around 35 million people over a decade, reports a worrying trend with cases doubling since 2022. For Thai readers, understanding the nature of this disease and its potential implications is crucial in a globally connected world where diseases can swiftly cross borders.

A new study from the Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center and collaborating researchers challenges the long-held view that low-carb ketogenic diets automatically raise heart disease risk due to higher LDL cholesterol. The findings arrive at a moment when keto dieting is popular in Thailand for weight management and health improvement, and they may influence dietary guidance for millions of people.

The research followed 100 individuals on long-term ketogenic plans and found that higher LDL cholesterol—often labeled the “bad” cholesterol—did not reliably predict increased cardiovascular risk in this group. Some participants remained metabolically healthy despite elevated LDL levels, known as lean mass hyper-responders (LMHR). This prompts a re-examination of conventional cholesterol risk models.

A recent study from The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, along with various research collaborators, challenges the long-held belief linking high cholesterol from low-carb ketogenic diets to increased heart disease risk. This study, which will likely spark significant discussions among health professionals and the general public alike, could reshape dietary recommendations for millions of individuals globally, including Thailand, where ketogenic diets have gained popularity among people seeking weight loss and improved health outcomes.

For millennia, the humble seeds of Pimpinella anisum—known in Thailand as “เทียนสัตตบุษย์” (Thian Sattabut), sometimes called anise or aniseed in English—have flavored foods, soothed countless ailments, and occupied a special niche in cultures from the Mediterranean to Southeast Asia. Today, as the world rediscovers the potential of traditional herbal remedies, modern science is shining new light on this ancient remedy, confirming some traditional claims and revealing promising new benefits. This article journeys into the fascinating world of เทียนสัตตบุษย์, exploring its rich history, traditional uses in Thai and global medicine, the chemistry that gives it power, and what current research says about its practical and safe use.

In a groundbreaking revelation, recent research published in the Journal of The Royal Society Interface has redefined our understanding of the aorta’s function within the human body. Known primarily as the primary conduit for oxygenated blood flowing from the heart to the rest of the body, the aorta has now emerged as a critical player that actively supports cardiovascular health. This discovery holds significant implications for individuals suffering from heart failure, a condition of growing concern in Thailand as well as globally.

A recent study is reshaping how we understand the aorta, the main artery that carries oxygen-rich blood away from the heart. Researchers say the aorta does more than passively absorb pressure spikes; it actively supports circulation through a mechanism called wave-pumping. This discovery could influence how heart failure is treated in Thailand and around the world.

Traditionally, the aorta was viewed as a flexible tube that cushions the heart’s workload by expanding and recoiling with each beat. Now scientists describe the aorta as a cooperative partner in blood flow. By stretching and recoiling in step with heart contractions, the aorta helps propel blood forward, effectively acting as a “second heart.” This could reduce the strain on a damaged heart and improve overall circulation, a welcome development for patients with heart failure.

Along Thailand’s riverside landscapes, the mighty mahad tree—Artocarpus lakoocha—has long stood as a symbol of healing. Its traditional extract, Puag Haad, is celebrated for cleansing the body and targeting parasites. Now, researchers examine how the heartwood’s compounds might benefit today’s health challenges, from intestinal infections to diabetes and skin concerns. The bridge between ancestral knowledge and modern science is growing stronger, with Thai researchers leading in evaluating safe, effective use.

Along the banks of lush Thai rivers and deep within the traditions of herbal wisdom, the tree known as Artocarpus lakoocha—or in local parlance, มะหาด (“mahat”)—stands tall as a symbol of healing heritage. Its storied extract, called Puag Haad (ปวกหาด), is a time-honored remedy in Thai medicine, celebrated for purifying the system and fighting parasites. Today, as a bridge between tradition and science takes shape, researchers are unraveling its secrets and exploring how the revered heartwood of this tropical tree may offer real benefits for modern ailments, from intestinal infections to diabetes and skin concerns.

For generations, lemongrass—locally known as ตะไคร้แกง or ตะไคร้บ้าน—has enjoyed a treasured status in kitchens and clinics across Thailand. Its unmistakable citrus fragrance infuses classic Thai curries, soups, and teas, while ancient healers and modern folk alike have praised its medicinal powers. Today, scientific studies are beginning to unlock the reasons behind the enduring reverence for this remarkable plant, illuminating the complex chemistry underpinning its traditional uses and raising fresh questions about its future role in natural health.

Lemongrass, known in Thai as ตะไคร้แกง or ตะไคร้บ้าน, has long flavored Thai kitchens and informed traditional healing practices. Its bright, citrus aroma graces curries, soups, and teas, while healers and contemporary herbalists alike have praised its medicinal potential. Today, scientists are clarifying why this plant has earned enduring respect, examining the chemistry behind its traditional uses and exploring its future role in natural health.

Cymbopogon citratus is more than a culinary symbol. It serves as a bridge between ancestral knowledge and modern inquiry. Grounding new findings in Thailand’s cultural and medical roots helps promote responsible, evidence-informed use that respects the nation’s heritage and keeps lemongrass relevant for younger generations seeking holistic wellness.