#Mooddisorders

Bipolar disorder, a complex mood disorder marked by dramatic oscillations between depression and mania, affects an estimated 40 million people worldwide. It is a condition that not only tests individuals’ emotional resilience but also challenges the medical community in its search for effective, personalized treatments. In a recent episode of NPR’s podcast Short Wave, a renowned psychiatry professor from Johns Hopkins School of Medicine—herself living with bipolar disorder—opened up about her diagnosis, daily management, and the latest advancements in treatment. Her dual role as scientist and patient offers a rare, deeply personal, and scientific insight into a condition that remains stigmatized and often misunderstood in many societies, including Thailand.

A major international research project led by the University of Ottawa is upending decades-old assumptions about how serotonin neurons function in the brain, with profound potential implications for treating mood disorders such as depression and understanding how our brains make binary decisions. Published in Nature Neuroscience on April 25, 2025, the study reveals that serotonin neurons—long thought to act as isolated units—actually form interconnected networks that collaborate and compete, orchestrating the brain’s serotonin output in ways far more complex than previously believed. The findings mark a major shift in neuroscience’s understanding of one of the brain’s most important neurotransmitter systems and open new avenues for targeted mental health therapies (Neuroscience News).

A groundbreaking new study published by an international research team led by the University of Ottawa is challenging decades-old beliefs about how serotonin works in the brain, uncovering a sophisticated web of interactions among serotonin neurons that could help redefine the treatment of mood disorders such as depression. Researchers found that instead of acting independently, clusters of serotonin neurons in the brainstem actively compete and collaborate, shaping both the timing and manner of serotonin release across different brain regions—a finding that overturns prior conceptions of a uniform serotonin signal and points to a more nuanced understanding of brain function and behavior (Neuroscience News).