#Myelin

A recent study by researchers at the University of the Basque Country, published in Nature Metabolism, found that marathon running can temporarily reduce myelin content in the brain. Importantly, these changes are fully reversible within two months, offering reassurance to endurance athletes concerned about lasting neural effects.

As Bangkok’s marathon scene grows, this finding is particularly relevant for Thai runners who tackle the 42-kilometer challenge. The study introduces the concept of metabolic myelin plasticity, suggesting that during intense exercise the brain may tap myelin lipids as an additional energy source when glucose is scarce. This aligns with established knowledge that glycogen stores deplete during long efforts, prompting the body to adapt its energy pathways.

A small, cutting-edge study suggests the brain may temporarily convert its own myelin into fuel during extreme endurance events like marathons. This unexpected mechanism could help protect overall brain function when glucose supply drops during intense exercise.

Researchers in Spain followed 10 marathon runners, scanning their brains with MRI before and after the races. They found that 24 to 48 hours after finishing a grueling 42-kilometer run, myelin levels in key brain regions—those governing movement, coordination, sensation, and emotion—decreased noticeably. Importantly, these changes were not permanent. By two weeks post-race, myelin began to recover, and most participants returned to baseline within about two months.

A groundbreaking pilot study has unveiled a fascinating aspect of human endurance, where during prolonged strenuous exercise like marathons, the brain might begin to ’eat’ itself by consuming its fatty sheath—myelin—for fuel. This unexpected finding adds a novel layer to our understanding of neuroplasticity, showcasing a radical adaptation strategy when glucose levels in the brain plummet.

The study, conducted by neuroscientists in Spain, involved 10 marathon runners who underwent MRI scans before and after their races. It was observed that 24 to 48 hours following the grueling 42-kilometer run, there was a significant reduction in myelin levels within regions of the brain crucial for motor skills, coordination, sensory, and emotional processing. Fortunately, these changes were not permanent. Just two weeks after the race, the myelin levels began to recuperate, and a full recovery was noted in most participants within two months.

In a fascinating new piIot study, neuroscientists suggest that the human brain may begin to “eat itself” during strenuous endurance exercises such as marathon running. This revelation comes from a team of researchers in Spain who observed intriguing changes in the brain’s white matter among marathon runners. Their findings present a novel form of neuroplasticity that could be crucial for maintaining cerebral functionality under extreme physical stress.

The researchers, led by Pedro Ramos-Cabrer and Alberto Cabrera-Zubizarreta, conducted MRI scans on the brains of ten marathon runners—eight men and two women—both before and after a 42-kilometer race. The scans depicted a marked decrease in myelin, a fatty layer that insulates nerve fibers and is integral for efficient communication between neurons. This reduction appeared uniquely pronounced in regions associated with motor function, coordination, sensory processing, and emotional integration. Remarkably, myelin levels began to rebound 24 to 48 hours post-race and were largely restored within two months for the six participants who continued with periodic scans.

A small pilot study suggests the brain may tap its own energy reserves during intense endurance efforts. Spanish researchers observed changes in brain white matter among marathon runners, hinting at a form of neuroplasticity that could help preserve function under extreme physical stress.

Researchers conducted MRI scans on ten endurance runners (eight men and two women) before and after a 42-kilometer race. The scans showed a measurable drop in myelin, the fat-rich sheath around nerve fibers that facilitates rapid signaling. The decrease was most evident in brain regions responsible for movement, balance, sensory processing, and emotion. Notably, myelin levels began to recover within 24 to 48 hours after the race and largely returned to baseline within two months for the six participants who had follow-up scans.