#Neuropharmacology

A new line of research suggests a gene-targeting approach could mimic the brain-protective effects of exercise, offering potential dementia prevention for Thailand’s aging population. The therapy targets pathways activated by physical activity, potentially helping elderly individuals who cannot engage in regular exercise due to mobility issues or advanced symptoms.

Thailand is undergoing a rapid demographic shift, with millions entering older age in the coming decade. Alzheimer’s disease and cognitive decline strain families, healthcare systems, and the broader economy. While exercise remains a cornerstone of brain health, many Thai seniors face barriers such as arthritis, chronic conditions, or limited access to fitness facilities.

A groundbreaking study from Harvard researchers has highlighted a novel approach to fighting cognitive decline associated with Alzheimer’s disease—one that does not require physical exertion but instead targets specific genes in the brain to replicate the beneficial effects of exercise. This research opens new avenues for treatments, particularly for those unable to engage in regular physical activity due to frailty or advanced symptoms.

Cognitive decline and Alzheimer’s disease remain pressing public health challenges globally, including in Thailand where a rapidly aging society faces rising rates of dementia. Traditionally, regular physical activity such as aerobic exercise has been strongly linked to slower cognitive deterioration and improved brain health. However, as experts note, many elderly patients—especially in the later stages of cognitive disorders—find it increasingly difficult to maintain an active lifestyle. This reality has driven scientists to explore the genetic and molecular pathways triggered by exercise, aiming to offer the same neuroprotective benefits via medical interventions.