#Nonspecificeffects

A growing body of research reveals that vaccines may deliver far more than protection against specific infectious diseases; they can also trigger broader immune system responses that benefit general health and survival, especially among children. These “non-specific effects”—sometimes called “bonus shots”—recently made headlines in a detailed feature on Salon.com, which highlighted a wave of new scientific findings and renewed international debate. For Thailand, where high childhood immunisation rates have underpinned rising life expectancies for decades, these revelations add new urgency and context to national vaccine policy.

Vaccines could do more than protect against a single infection. Recent research suggests some vaccines may strengthen overall immune health, potentially benefiting children beyond the targeted diseases. In Thailand, this idea is reshaping discussions about child-immunization programs and how schedules might adapt in the future.

Live vaccines, including BCG for tuberculosis and the measles vaccine, have shown associations with lower mortality from a variety of causes not limited to the diseases they prevent. Researchers emphasize that these broader benefits may stem from how vaccines train the immune system. Thai health professionals are exploring what this could mean for vaccination timing, policy decisions, and parental choices.