#OpioidCrisis

US health officials have launched a major crackdown on kratom-related products, targeting an opioid-like compound known as 7-hydroxymitragynine—often called “7-OH”—after a surge of complaints from the dietary supplement industry and growing safety concerns among regulators and medical experts. The US Food and Drug Administration (FDA) recently announced its intention to classify 7-OH as a Schedule I controlled substance, placing it on par with substances like LSD and heroin, and recommending a nationwide ban pending Drug Enforcement Administration (DEA) review (WBRZ; Yahoo News; FDA).

Recent research into the brain’s natural mechanisms for managing pain reveals fascinating insights that could revolutionize the way we approach pain management. At the heart of this discovery is the periaqueductal grey (PAG), a brain region that plays a crucial role in suppressing pain even before it reaches our conscious awareness. This study explains why individuals with severe injuries, such as soldiers during WWII, sometimes feel little to no pain and opens potential pathways for non-opioid pain therapies.