#Orthopaedics

A breakthrough preclinical study has revealed that clearing “zombie cells” from spinal discs may dramatically reduce chronic low back pain, a condition that affects millions of people globally and remains common among Thais. Researchers from McGill University found that two drugs—o-Vanillin and RG-7112—can target and remove these senescent cells, leading not only to reduced pain and inflammation but even signs of tissue repair in damaged spinal discs. The findings, published in Science Advances, point to a transformative new treatment that addresses the root cause of back pain rather than just masking symptoms with painkillers or surgery source.

A preclinical study suggests that removing senescent or “zombie” cells from spinal discs may dramatically reduce chronic low back pain. Researchers at McGill University found that two drugs, o-Vanillin and RG-7112, can target and clear these cells, leading to reduced inflammation and signs of tissue repair in damaged spinal discs. The findings, published in Science Advances, point to a potential treatment that addresses the root causes of back pain rather than simply masking symptoms with painkillers or surgery.