Paternal Exercise May Pass Benefits to Offspring Through Sperm MicroRNAs, New Research Suggests
A groundbreaking study from researchers at Nanjing University and Nanjing Medical University suggests that the benefits of a father’s exercise can be passed down to his children. The mechanism is not through DNA sequence changes, but through tiny molecules in sperm called microRNAs that reprogram early embryo development. In experiments modeled in animals, offspring of exercise-trained fathers showed better endurance and healthier metabolic profiles. Even more striking, injecting sperm small RNAs from exercised fathers into normal embryos reproduced these benefits in the next generation. The work centers on a master regulator of energy metabolism, PGC-1α, and a molecular partner in early development called NCoR1, mapping a clear, testable path from paternal behavior to offspring health.