Peptide map of fear points to new PTSD treatments for Thailand
New laboratory work shows neuropeptides — long neglected in favour of fast neurotransmitters — can act as primary messengers in distinct brain circuits for panic and fear, offering new drug and therapy targets for trauma-related disorders such as PTSD. Recent studies using novel genetically encoded sensors and circuit-specific manipulations identify a PACAP-driven panic pathway in the brainstem and peptide-dominated signalling in threat-learning circuits, while separate research implicates endocannabinoid action in stress-driven generalisation of fear memories. These advances explain why panic, conditioned fear and memory generalisation can behave differently, and point to concrete directions for Thai mental-health policy, clinical practice and research investment. ( Chemistry World feature: The chemistry of fear )