#PersonalisedMedicine

In Thailand’s evolving mental health landscape, depression often hides behind cultural norms of resilience. Yet a profoundly disruptive symptom—anhedonia, or the loss of interest or pleasure—affects up to seven in ten people with clinical depression and demands urgent attention within Thai healthcare.

Anhedonia is more than laziness or lack of motivation. It reflects fundamental changes in the brain’s reward system and can persist even as other depressive symptoms improve. For millions of Thais with undiagnosed or undertreated depression, understanding anhedonia’s role in treatment resistance and suicide risk could reshape therapy while addressing stigma around mental illness.

Within Thailand’s expanding mental health discourse, where depression often remains hidden behind cultural expectations of resilience and social harmony, researchers worldwide are illuminating a critical but overlooked symptom that makes recovery exponentially more challenging. Anhedonia—the profound loss of interest or pleasure in previously enjoyable activities—affects up to 70% of individuals with clinical depression, yet receives minimal attention in Thai healthcare settings where mood disorders are frequently reduced to simple sadness narratives.

A newly published research review is spotlighting an often overlooked—and intensely difficult—symptom at the heart of depression: anhedonia, the loss of interest or pleasure in once-enjoyable activities. This critical symptom, psychiatrists say, not only makes depression harder to treat but also increases the risk of chronic suffering. Recent scientific efforts unravel the complex roots and persistence of anhedonia, suggesting new ways forward for both patients and health professionals, including targeted therapies and hope for personalised interventions (WebMD).