#Pharmacology

Cutting-edge research by scientific teams at Mount Sinai Hospital represents a fundamental breakthrough in understanding emotional regulation within the brain, potentially opening pathways to more precise, faster-acting psychiatric therapies for millions living with depression, anxiety, and related conditions throughout Thailand and globally. Recent study published in Science Advances reveals that a phospholipid fat molecule embedded deep within brain cell membranes acts as hidden regulatory partner to a vital mood-controlling receptor, providing unprecedented insights that could revolutionize mental health treatment approaches and offer new hope for patients who have not responded adequately to existing therapeutic options.

A cutting-edge discovery by research teams at Mount Sinai Hospital is rewriting what we know about how emotions are regulated in the brain, potentially pointing to new hope for millions living with depression, anxiety, and related conditions. A study published recently in Science Advances has found that a fat molecule called a phospholipid, deep within our brain cell membranes, acts as a hidden “co-pilot” to a vital mood-regulating receptor. This fundamental insight could pave the way for more precise, faster-acting psychiatric therapies—with implications for mental health care in Thailand and across the world (neurosciencenews.com).

In the realm of Thai traditional medicine, few remedies are as steeped in both mystery and reverence as ยาจันทน์ลีลา (Chandra Leela). Often found in pharmacies with gold script on bottles and issued as small, pungent brown pills, Chandra Leela has found its place in the medicine cabinets of countless Thai families. For centuries, this traditional herbal mixture has offered hope and relief, particularly for those afflicted with fever or flu-like symptoms. But what is the history behind this celebrated remedy, what are its true ingredients, and does science validate its claims? As Thailand and the world’s curiosity for plant-based therapies grows, Chandra Leela finds itself at the intersection of ancient wisdom and modern investigation.

Millions of children in the United States are diagnosed with attention-deficit hyperactivity disorder (ADHD), and the vast majority are prescribed stimulant medications such as Ritalin and Adderall. However, a new wave of research reported by NPR and detailed in The New York Times Magazine raises pressing questions about the effectiveness and long-term consequences of these treatments, as well as the very nature of ADHD itself (NPR, 2025).

The U.S. Centers for Disease Control and Prevention (CDC) revealed last year that more than 11% of American children had received an ADHD diagnosis—a record high, and a dramatic increase from the early 1990s figure of just 2 million. In 14-year-old boys, the rate soars to 21%. These statistics portray a nation deeply invested in identifying—and medicating—children with ADHD. But why are diagnoses rising, and are treatments truly serving those diagnosed?

With its thorn-laced stems coiling through the forests of Southeast Asia, the Khon Tha plant—known to scientists as Harrisonia perforata—has been steeped in Thai healing traditions for centuries. Revered under many local names, including กะลันทา (Kalantha) and โกทา (Kota), Khon Tha’s story exemplifies the enduring power of traditional remedies—and the renewed scientific curiosity that is bringing age-old practice into the spotlight. As health-conscious Thais seek both ancestral wisdom and clinical evidence, the bridge between local herbal folklore and modern biomedical validation becomes more vital than ever.

For centuries, the slender, finger-like fruit known as ดีปลี (Dipli)—or long pepper to the wider world—has been valued in Thai kitchens and medicine cabinets alike. Revered for its spicy-hot kick and its potent medicinal reputation, Dipli has traveled the journey from sacred ritual and home remedy to the laboratory bench, where new research is validating some ancestral claims while raising important questions about its safety and efficacy. Today, this unassuming fruit—harvested just before ripening from the Piper retrofractum vine—stands at a crossroads between tradition and science, inviting curious minds and health enthusiasts to discover its story.

For centuries, the aromatic root of Angelica sinensis—known in Thailand as โกฐเชียง (got chiang) and widely as “Dong Quai” or “Tang Kuei”—has held a mystical place in traditional Asian medicine. Cherished in classic Chinese and Thai remedies for women’s health, this unassuming root is both steeped in cultural tradition and, increasingly, the subject of scientific scrutiny. Today, Dong Quai’s tale offers a fascinating lens through which Thai readers can see the interplay between ancient botanical knowledge, deep-rooted cultural beliefs, and the ever-evolving rigor of modern research.

To anyone familiar with the fragrant world of traditional Thai and Chinese herbal medicine, few roots embody such history and medical promise as kot kraduk (โกฐกระดูก), known scientifically as Aucklandia lappa DC. and in Chinese as mu xiang (木香). With its distinctive aromatic qualities, kot kraduk—once procured chiefly from trade routes stretching into the Himalayas—has been renowned for centuries across Asia as a mainstay of herbal prescriptions for digestive, pain, and inflammatory conditions. As scientific advances probe the truths behind ancient healing, kot kraduk emerges as a fascinating case where tradition and research meet.

Deeply embedded in the fragrant traditions of Asia, the camphor tree – known locally in Thailand as “การบูร” and scientifically as Cinnamomum camphora – has captivated generations with its distinctive aroma and remarkable healing properties. Revered as much in temple rituals as in household medicine chests, camphor (การบูร) bridges the world of ancient herbal wisdom and contemporary pharmacological research, serving as a vivid illustration of how tradition and science can intertwine for the benefit of health-conscious individuals today.