Depression subtyping could reshape treatment in Thailand, researchers say
A new analysis of UK Biobank data using advanced brain imaging reframes depression as three distinct symptom groups rather than a single disorder. The clusters are: mood-dominant, motivation-dominant, and a combination of both. Each group shows unique brain activation patterns and responds differently to treatment approaches, suggesting more precise, personalized care.
Researchers from Washington University School of Medicine and collaborators argue that this symptom-driven view challenges traditional one-size-fits-all therapies. For Thai clinicians and policymakers, the work points to new ways to tailor interventions to neurobiological profiles, potentially improving outcomes in Thailand’s evolving mental health system.