#Phytochemistry

For centuries, the humble แห้วหมู (Cyperus rotundus L.)—also known as หญ้าแห้วหมู or หัวแห้วหมู in various parts of Thailand—has held an esteemed place in traditional Thai herbal medicine cabinets and village gardens. Revered across Asia and beyond for its underground tubers, this unassuming sedge has been a symbol of resilience and healing. Today, a wave of renewed scientific interest is validating aspects of its age-old uses, connecting ancestral knowledge with the rigors of modern clinical research. With daily lives increasingly marked by stress, chronic conditions, and lifestyle diseases, Thai readers are seeking both hope and evidence in remedies that endure from the past.

In the heart of Thai traditional medicine, where ancient wisdom merges with daily wellness, the humble dried ginger, known in scientific circles as Zingiber ligulatum Roxb., stands as a quiet champion. Prized for generations throughout Southeast Asia, especially in Thailand, this distinct member of the Zingiberaceae family is celebrated not only as a culinary spice but also as a key player in indigenous healing rituals. Today, as researchers turn a critical eye to herbal remedies, the traditional uses and chemical treasures of Zingiber ligulatum are being re-examined under the lens of modern science—with fascinating results.

Few ingredients so vividly capture the essence of Thai cuisine and culture as the small, vibrant green fruit known throughout the country as manao. While most Thai people recognize it as an indispensable flavor booster in dishes like tom yum, som tam, and countless chili dips, the leaves, bark, and fruit of Citrus aurantiifolia—more commonly called lime—hold a much deeper significance that extends well beyond the kitchen. The traditional uses of manao stretch back centuries, rooted in household remedies and ancient wisdom, while mounting scientific evidence is beginning to illuminate the bioactive magic that has long made lime a staple for both taste and health. Today, as health-conscious Thai readers seek to reconnect with their heritage and examine time-honored remedies with new eyes, the story of manao becomes both a case study in the enduring power of traditional herbal medicine and a testament to how modern research can inform and evolve ancient practices.

In the vibrant gardens and medicinal lore of Thailand, few remedies have captivated both traditional healers and modern scientists as profoundly as เจตมูลเพลิงแดง (Plumbago indica L.), known locally by names such as ปิดปิวแดง in the North, and ไฟใต้ดิน in the South. This striking shrub, with its scarlet flowers and powerful roots, has a centuries-old presence in Thai folk medicine. Yet, in the past decade, this botanical treasure is increasingly stepping into the scientific spotlight, as contemporary research begins to validate and explain much of what Thai healers have long believed.

For generations, communities across Thailand have celebrated the deep-rooted legacy of มะดูก (Maduk), or Siphonodon celastrineus Griff., integrating it into a rich tapestry of traditional herbal medicine. Local names such as บักดูก (Isan), บักโคก (Khmer), and ยายปลวก (South) reflect its widespread recognition, while the regional moniker ดูกหิน hints at its multifaceted roles in Thai life. Today, as a wave of scientific curiosity washes over ancient remedies, Maduk stands at a fascinating crossroads: its historical healing wisdom now meets the transformative lens of modern pharmacology. How does tradition measure up to laboratory scrutiny, and what can health-conscious readers in Thailand glean from this botanical heritage?

In the lush backyards and traditional herbal pharmacies of Thailand, the vivid blooms and distinctive red-tinted roots of Plumbago indica—commonly known as เจตมูลเพลิงแดง (jetmool phloeng daeng)—have for centuries lent their magic to remedies, rituals, and recipes. Now, as scientists turn their microscopes and test tubes toward this remarkable root, Plumbago indica finds itself at the lively intersection of tradition and technology, embodying both the country’s botanical heritage and its quest for evidence-based healing.

In the heart of Thailand’s forests, beneath the dappled shade of towering trees, thrives an ancient plant with fronds vast and regal: ว่านกีบแรด, known in scientific circles as Angiopteris evecta. For generations, this grand fern—often referred to in Thai as “กีบม้าลม” or “กีบแรด,” and in English as the king or elephant fern—has occupied a unique place in traditional medicine cabinets. Today, as modern research catches up, the world is beginning to understand and appreciate the therapeutic virtues that Thai healers have long extolled.

For generations across Thailand and Southeast Asia, the striking leaves of หมากผู้หมากเมีย (Cordyline fruticosa) have adorned gardens and temples not just for their beauty but for their revered properties in traditional medicine. This “good luck plant,” recognizable for its vibrant, palm-like foliage, stands at the intersection of ancient healing wisdom and contemporary scientific inquiry. Increasingly, researchers have begun to untangle the story behind this botanical treasure—known by many Thais as มะผู้มะเมีย, หมากผู้, or ปูหมาก—to validate, reinterpret, and, in some cases, challenge inherited knowledge in light of emerging pharmacological evidence. What does science now say about the long-trusted remedy, and how should modern Thais approach its continued use?

Among the lush, shaded understories of Thailand’s tropical forests grows a plant shrouded in both botanical intrigue and cultural tradition—the enigmatic Tacca chantrieri, known locally as “Nerapusee Thai,” or more vividly as the “black bat flower.” With striking purplish-black petals that mimic a bat in flight, this unusual plant has captured both the imaginations of herbalists and the attention of modern scientists, standing at the crossroads of folklore and pharmacology.

For centuries, Thais have turned to the earth for remedies, drawing healing from roots and herbs used by traditional healers. Among the constellation of Thailand’s ancient plant medicines, “Phitsanat” (พิษนาศน์), known in scientific parlance as Sophora exigua Craib, holds a special place in the country’s folk pharmacopoeia. Also recognized by a bouquet of names such as แผ่นดินเย็น, นมราชสีห์, and สิบสองราศี, Phitsanat’s journey from rural village gardens and temple courtyards into the realm of modern pharmacology is a paradigm of the enduring dialogue between tradition and science. Today, as Thailand seeks to harmonize its cultural heritage with advancements in healthcare, Phitsanat is once again in the spotlight—this time, not just through the whispered wisdom of healers, but under the scrutiny of laboratory lights.

From the bustling wet markets of Bangkok to the rural kitchens and home altars of Isan, the aromatic rhizome known as เปราะหอม—Kaempferia galanga—has quietly permeated Thai life for centuries. Once reserved for ancient healers, royal courtiers, and spiritual practitioners, this humble root has survived countless health trends, outlasting many in the cultural imagination and emerging today as both a celebrated culinary spice and a growing subject of modern pharmacological curiosity. How does this ancient Thai remedy stack up against the rising tide of scientific scrutiny, and what can a new generation of health-conscious Thais learn as we rediscover its potential?

Saba (สะบ้า), known to botanists as Entada rheedii Spreng., is a giant climber found winding its way through Thailand’s forests, bearing massive pods filled with glossy, oval seeds. Known by many local names—สะบ้ามอญ, สะบ้าใหญ่, มะบ้าหลวง, มะนิม, หมากงิม, and more—this remarkable plant holds a special place in traditional Thai and Southeast Asian herbalism. Yet, while Saba’s seeds have long been a source of healing, ceremony, and even magic, a new chapter is unfolding as science begins to validate—and sometimes challenge—the wisdom sewn into local customs. For Thai readers curious about natural health solutions with ancient roots, Entada rheedii represents a fascinating intersection of folklore, pharmacology, and global botanical research.

For generations, the deep reddish-brown extract known as สีเสียดไทย (Si Sied Thai), derived from the heartwood of the Acacia catechu tree, has been a staple in Thai herbal pharmacies and village medicine chests alike. Once a ubiquitous remedy for diarrhea, sore throat, and wounds, Si Sied Thai is now drawing fresh scientific interest for its rich array of antioxidants and bioactive compounds. But does this ancient astringent live up to its venerable role, or is it simply a relic of another era? Recent laboratory studies, cultural documentation, and emerging pharmacological findings suggest the answer is a fascinating blend of both tradition and science, urging a new generation to look again at its unique healing potential.

For generations, Thai wisdom keepers have regarded ส้มโอมือ (sôm o mue), or Citrus medica L.―known in English as ‘Buddha’s Hand’, citron, or ส้มมือ (sôm mue)—as a fragrant gift from nature, thriving across temple gardens, village fences, and the annals of ancient pharmacopeias. In an era where health-conscious readers yearn for authentic remedies grounded as much in heritage as in evidence, ส้มโอมือ shines as both a cultural artifact and a rising star of modern pharmacological research. Today, as science investigates the very compounds once praised by village healers, a fascinating convergence emerges: ancient Thai medicinal practices are increasingly gaining validation in the global scientific narrative.

For centuries, the spiny shrub known to Thais as “som poi” has quietly played a role in kitchens, bathing rooms, and healing traditions across the country. From using its pods as a cleansing shampoo to brewing its leaves for herbal teas, Acacia concinna—once a staple in village life—is now at the center of a scientific renaissance, as researchers unravel its ancient secrets and unlock new health possibilities for the modern age (prosea.prota4u.org; phar.ubu.ac.th).

For centuries, สีเสียดเทศ—known scientifically as Uncaria gambir—has been a trusted remedy in the apothecaries and homes throughout Southeast Asia. Revered in both Thai and wider Southeast Asian herbal traditions, it has historically served as a versatile medicinal ally, from soothing stomach complaints to tending to wounds. Today, สีเสียดเทศ’s transformation from regional folk remedy and trade commodity to a subject of modern pharmacological research reveals a vibrant intersection of culture, tradition, and science—one that offers intriguing prospects, but also calls for careful scrutiny and respect.

Tucked beneath a thick, glossy purple rind, the delicate snow-white segments of mangosteen have long enchanted anyone lucky enough to taste them. Revered throughout Southeast Asia and lovingly dubbed the “Queen of Fruits,” this tropical treasure has inspired myths, royal favor, and deep respect among traditional healers. Today, mangosteen stands at the fascinating crossroads of ancient herbal wisdom and cutting-edge biomedical research, offering a compelling story for Thai readers and global health enthusiasts alike.

Tucked within the lush forests and hills of Thailand, an evergreen climber known locally as เมื่อยแดง (Gnetum macrostachyum) has woven itself into the fabric of traditional medicine for generations. With monikers like เมื่อยดูก, ม่วยแดง, เมื่อยเลือด, and กำแพงเพชรเจ็ดชั้น, this resilient vine is more than botanical curiosity—it is a symbol of local wisdom and a promising subject for scientific discovery. Recent research has started peeling back the layers of folk knowledge, finding that this traditional remedy may indeed hold genuine pharmacological potential, offering a fascinating convergence of ancient healing rituals and contemporary biomedical science.

Across the rice fields and riverbanks of Thailand’s Northeast, stories spin about a curious plant whose roots are as twisted as the folklore surrounding them. Known as “ปลาไหลเผือกน้อย” (pla lai phueak noi) or regionally as “เอี่ยนด่อน,” Eurycoma harmandiana Pierre has woven itself into the medicinal traditions of Thai and neighboring Lao communities for generations. Bearing a name that translates to “white eel” in local dialects—“เอียน” meaning eel and “ด่อน” denoting the white color—this small but potent shrub holds a revered place in Isan folk practice as a source of wellness, vitality, and resilience, cherished particularly for its powerful roots.

For centuries, the aromatic leaves and knobbly fruits of the kaffir lime—known in Thai as makrut—have graced Thai kitchens, ritual spaces, and medicine cabinets. Its distinctive fragrance is instantly recognisable in tom yum soup and green curry, yet beyond its culinary appeal lies a trove of traditional healing wisdom. Today, scientists are delving deep into this humble plant’s chemistry, revealing how ancient practices may be supported—and sometimes challenged—by modern research.

Thailand’s lush forests have long been a pharmacy for its people, with “เปล้าใหญ่” (Pao Yai or Croton oblongifolius Roxb.) prized as both a household herbal medicine and a subject of modern scientific inquiry. Once the preserve of village healers and traditional midwives, the leaves of Pao Yai are now being examined with the lens of pharmacological research, offering a fascinating bridge between the wisdom of the ancients and the rigor of modern science. As health-conscious Thais and global communities turn to natural options, understanding the story of Pao Yai opens a window on how local plants can support—yet must never replace—conventional healthcare, especially as research unfolds.

For centuries, Borapet (Tinospora crispa)—also known in different Thai regions as khruea khao ho, chong ching, or jetamoon yam—has twined its bitter stems through local gardens, folk medicine chests, and herbal lore across Thailand and Southeast Asia. Praised by elders for its invigorating and cooling qualities, Borapet has long been a household staple for treating a perplexing range of ailments: from fevers and diabetes to wound healing and indigestion. Today, as modern science turns its gaze toward ancient remedies, Borapet’s reputation as a local panacea is receiving fresh scrutiny—and, in some cases, careful scientific validation.

For centuries, Tūmka—the modest seed from the Strychnos nux-blanda tree—has held a mysterious place in Thai folk medicine. Known under a constellation of regional names, including “Kotkakling”, “Khimka”, “Makting”, and “Sa Laeng Jai”, the seed’s reputation oscillates between being a powerful remedy and a perilous poison. With its origins woven through the rural and traditional communities of Thailand, Tūmka continues to intrigue both cultural custodians and biomedical scientists alike. But how much of its legacy stands up to modern science—and what should health-conscious readers know if they encounter this potent botanical?

In the world of Thai traditional medicine, few herbal remedies are as multi-faceted, aromatic, and steeped in history as chaluud (ชะลูด). Harvested mainly from the bark of Alyxia reinwardtii—also known locally as “luud,” “chanud,” or “nood” depending on region—chaluud has perfumed Thai homes and pharmacies for centuries. Today, as interest in natural medicines grows worldwide, this “white cinnamon” is drawing modern scientific scrutiny, revealing an intriguing intersection between age-old folk wisdom and contemporary pharmacological research.