#Placeboeffect

The latest in-depth investigations by international psychiatrists and psychologists are prompting a global rethink over the widespread use and perceived efficacy of antidepressants, especially in the United States, where such medications have become almost ubiquitous for treating depression, anxiety, and insomnia. New findings sharply question the central assumptions about how these drugs work, their long-term benefits, and the risks they carry—a discussion that resonates far beyond America’s borders, including in Thailand, as local mental health practices continue to evolve.

A wave of international research is prompting a global rethinking of how antidepressants are prescribed, especially in the United States where these drugs are widely used to treat depression, anxiety, and sleep problems. New findings challenge long-held beliefs about how these medications work, their long-term benefits, and their risks. The implications extend beyond the U.S., influencing mental health practices in Thailand as local care evolves.

In recent years, antidepressants moved from tightly controlled clinical tools to commonly endorsed remedies. Guidelines in some parts of the United States often recommend antidepressants as a first-line treatment for mild to moderate depression, a stance that contrasts with guidance from global health authorities and Thai care providers who emphasize caution for milder cases. The Covid-19 era saw a surge in prescriptions, underscoring a strong reliance on these medications within American health systems.