#Precisionmedicine

A Swedish-led randomized trial has found that a low dose of aspirin given after surgery can dramatically reduce the risk of colorectal cancer returning, but only in patients whose tumors carry a specific genetic alteration in the PIK3 signaling pathway. In the ALASCCA study, more than 3,500 patients across 33 hospitals in Sweden, Norway, Denmark, and Finland were followed after colorectal tumor removal. Those with the PIK3 mutation who took 160 milligrams of aspirin daily for three years experienced a 55 percent reduction in recurrence compared with those who received a placebo. The findings, published in a prestigious medical journal, represent a landmark for precision medicine in colorectal cancer, suggesting that a cheap, globally available drug could become an integral part of post-surgical care for a defined subgroup of patients.

A groundbreaking new study has unveiled how transformative interactions between exercise, gut microbes, and the immune system may significantly improve the effectiveness of cancer immunotherapy—a revelation that could inspire new treatment strategies for Thai cancer patients and shape global oncology protocols. Researchers at the University of Pittsburgh, publishing in the journal Cell, demonstrated for the first time in mice that exercise reshapes the gut microbiome, leading to the production of a powerful compound called formate, which boosts the body’s cancer-fighting immune response and enhances outcomes from immunotherapy (medicalxpress.com).

A new study links exercise, gut microbes, and the immune system, offering a potential way to improve cancer immunotherapy for Thai patients. Researchers at a leading U.S. university found that regular exercise reshapes the gut microbiome and increases a metabolite called formate. Formate enhances CD8 T cells, strengthening the body’s attack on cancer and improving responses to immune checkpoint inhibitors. The findings point to a practical, accessible approach to boost treatment outcomes in Thailand and inform global oncology practices.

A new wave of cancer care is emerging: exercise is not just a supplement but a targeted intervention that can influence cancer biology and treatment outcomes. Research from the Exercise Oncology Program at Memorial Sloan Kettering Cancer Center shows that a carefully prescribed exercise plan can counteract treatment side effects and support recovery. For Thai readers facing cancer, this direction offers practical, evidence-based steps beyond traditional medicine.

Historically, patients were urged to rest during treatment. Today, scientists are rethinking inactivity. Spaceflight and chemotherapy-related fatigue share striking similarities, including muscle and cognitive decline. Dr. Jessica Scott, a leader in exercise oncology who previously worked with NASA, notes that both cancer patients and astronauts can benefit from movement. The key is tailoring activity to each person’s situation, an approach Dr. Scott has applied from space medicine to oncology.

A groundbreaking shift in cancer treatment is underway, as emerging scientific evidence highlights exercise not just as a supplement to traditional therapies but as a powerful intervention in its own right. Recent research led by the Exercise Oncology Program at Memorial Sloan Kettering Cancer Center (MSK) has demonstrated that strategically prescribed exercise can meaningfully influence cancer biology, helping to counteract the damaging effects of treatment while potentially improving patient outcomes. For Thai readers facing cancer, this latest research marks a promising new direction, offering hope and actionable steps beyond conventional medicine.

A leading American cardiologist has issued a clarion call to cut through the rising tide of pseudoscience and embrace rigorous, evidence-based strategies to extend both the length and quality of human life. In his newly released book “Super Agers: An Evidence-Based Approach to Longevity,” Dr. Eric Topol, founder and director of the Scripps Research Translational Institute, condemns the proliferation of bio-hacking, anti-vaccine conspiracy theories, and unfounded “anti-aging” movements that have gained ground, particularly in the wake of the COVID-19 pandemic [The Guardian].

A renowned American cardiologist argues that society should discard pseudoscience and embrace science-backed strategies to extend both lifespan and healthspan. In his new book, Super Agers: An Evidence-Based Approach to Longevity, Dr. Eric Topol, founder and director of the Scripps Research Translational Institute, condemns bio-hacking, anti-vaccine rhetoric, and unfounded “anti-aging” movements that gained momentum after the COVID-19 pandemic. The takeaway is clear: a rigorous, evidence-driven approach can prevent the three major age-related diseases and improve quality of life.

A new imaging method promises a leap forward for brain-body research with a high-resolution, minimally invasive look at the brainstem’s hub for body-signal processing. Researchers say D-PSCAN reveals the nucleus tractus solitarii (NTS) in living animals without disturbing the cerebellum, offering a clearer view of how bodily signals shape mood and mental health. This advancement could transform how depression and related disorders are diagnosed and treated, and it has clear relevance for Thai clinicians seeking innovative tools.

In a significant leap forward for neuroscience, researchers have unveiled a revolutionary imaging technique that allows high-resolution, minimally invasive observation of the brainstem’s critical hub for processing bodily signals—a discovery with the potential to transform treatment for depression and other mental health disorders. The new approach, called D-PSCAN, opens an unprecedented window onto the nucleus tractus solitarii (NTS), a deep-brain structure that integrates signals from the body and helps regulate emotions and overall mental health (Neuroscience News).

A new research breakthrough has introduced a blood test capable of detecting tumor-derived cell-free RNA with remarkable sensitivity, potentially revolutionizing the approach to cancer diagnosis and monitoring in Thailand and around the globe. The study, recently highlighted in Medical Xpress, outlines how scientists have developed a test that can identify even minuscule traces of RNA released by cancer cells into the bloodstream, leading to the possibility of earlier and less invasive cancer detection.

A new blood test can detect tumor-derived cell-free RNA with notable sensitivity, potentially transforming cancer diagnosis and monitoring for Thai patients and beyond. Researchers describe a method that identifies tiny traces of RNA released by cancer cells into the bloodstream, opening the door to earlier, less invasive detection.

Cancer remains a leading health challenge in Thailand, where late-stage diagnoses often limit treatment options and worsen outcomes. The test targets fragments of tumor-derived RNA, which carry genetic instructions from DNA to cells, offering a chance to spot cancer at its earliest, most treatable moments.

A groundbreaking new study has revealed that extremes in brain synchrony—either too much or too little—may underlie distinct subtypes of autism, offering Thai families, educators, and clinicians fresh hope for more tailored approaches to diagnosis and support. Published on 17 April 2025 in The Transmitter, the research used advanced brain imaging across twenty mouse models genetically engineered to mimic autism, with remarkable implications for understanding the diversity—or heterogeneity—of the autism spectrum in humans (The Transmitter, 2025).

An international team has produced the first detailed three-dimensional map of a mammal’s brain, revealing unprecedented insight into brain structure and function. Focusing on a tiny fragment of a mouse’s visual cortex, the achievement marks a milestone for neuroscience with potential to improve diagnosis and treatment of brain diseases such as Alzheimer’s and autism. For Thai readers, the findings underscore how advances in brain science can influence medicine, education, and future AI applications amid Thailand’s aging society.

A new study suggests that extreme brain synchrony—either too high or too low—may define distinct autism subtypes. The finding offers fresh hope for Thai families, educators, and clinicians seeking more personalized approaches to diagnosis and intervention. The research, published on 17 April 2025 in The Transmitter, used advanced brain imaging across twenty mouse models designed to mimic autism and explored how brain regions coordinate activity. The study’s implications extend to understanding the heterogeneity of autism in humans.

In a scientific breakthrough once thought impossible, an international team of researchers has created the first detailed three-dimensional map of a mammal’s brain, offering an unprecedented window into the structure and function of the mind. This ambitious feat, achieved by studying a tiny fragment of a mouse’s visual cortex, marks a pivotal advance in neuroscience and holds profound implications for understanding brain diseases such as Alzheimer’s and autism (CNN/Yahoo! News).

A breakthrough from a leading U.S. university promises to redefine how Alzheimer’s is diagnosed and monitored. Researchers describe a blood test that identifies the disease and tracks its progression, offering a less invasive and potentially more affordable option. For Thailand, with an aging population, such a tool could help healthcare systems scale screening and early intervention.

Alzheimer’s disease slowly erodes memory and cognitive function. Traditional diagnosis combines cognitive assessments, brain imaging, and sometimes invasive procedures to detect hallmark proteins such as amyloid-beta and tau. These methods may miss early signs when treatment is most effective.